TMEM176A (transmembrane protein 176A)

2003-06-01  

Identity

HGNC
TMEM176A
LOCATION
7q36.1
LOCUSID
55365
ALIAS
GS188,HCA112,MS4B1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55365
MIM: 610334
HGNC: 24930
Ensembl: ENSG00000002933

Variants:

dbSNP: 55365
ClinVar: 55365
TCGA: ENSG00000002933
COSMIC: TMEM176A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000002933ENST00000004103Q96HP8
ENSG00000002933ENST00000004103A0A090N8H6
ENSG00000002933ENST00000461345C9JJ63
ENSG00000002933ENST00000468689C9JJ63
ENSG00000002933ENST00000475536H7C4P5
ENSG00000002933ENST00000484928Q96HP8
ENSG00000002933ENST00000484928A0A090N8H6

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
222444482012Abnormal accumulation of human transmembrane (TMEM)-176A and 176B proteins is associated with cancer pathology.29
286786482017Methylation of TMEM176A is an independent prognostic marker and is involved in human colorectal cancer development.8
270094672016RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.5
304009682018Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma.1
289024592017Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci with potential implications for neurocognitive performance.0

Citation

Dessen P

TMEM176A (transmembrane protein 176A)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40792/tmem176a