TMEM176B (transmembrane protein 176B)

2012-11-01  

Identity

HGNC
LOCATION
7q36.1
LOCUSID
ALIAS
LR8,MS4B2
FUSION GENES

Other Information

Locus ID:

NCBI: 28959
MIM: 610385
HGNC: 29596
Ensembl: ENSG00000106565

Variants:

dbSNP: 28959
ClinVar: 28959
TCGA: ENSG00000106565
COSMIC: TMEM176B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106565ENST00000326442Q3YBM2
ENSG00000106565ENST00000326442A0A090N7V7
ENSG00000106565ENST00000429904Q3YBM2
ENSG00000106565ENST00000429904A0A090N7V7
ENSG00000106565ENST00000434545Q3YBM2
ENSG00000106565ENST00000434545A0A090N7V7
ENSG00000106565ENST00000447204Q3YBM2
ENSG00000106565ENST00000447204A0A090N7V7
ENSG00000106565ENST00000450753Q3YBM2
ENSG00000106565ENST00000492607Q3YBM2
ENSG00000106565ENST00000492607A0A090N7V7

Expression (GTEx)

0
100
200
300
400
500
600
700

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
359804842023The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation.5
359804842023The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation.5
349439382021TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in Triple-Negative Breast Cancer.2
349439382021TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in Triple-Negative Breast Cancer.2
313540342020TMEM176A and TMEM176B Are Candidate Regulators of Inhibition of Dendritic Cell Maturation and Function after Chronic Spinal Cord Injury.20
313540342020TMEM176A and TMEM176B Are Candidate Regulators of Inhibition of Dendritic Cell Maturation and Function after Chronic Spinal Cord Injury.20
270094672016RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.22
270094672016RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.22
222444482012Abnormal accumulation of human transmembrane (TMEM)-176A and 176B proteins is associated with cancer pathology.47
222444482012Abnormal accumulation of human transmembrane (TMEM)-176A and 176B proteins is associated with cancer pathology.47

Citation

Dessen P

TMEM176B (transmembrane protein 176B)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52943/tmem176b