TMEM18 (transmembrane protein 18)

2014-06-01  

Identity

HGNC
TMEM18
LOCATION
2p25.3
LOCUSID
129787
ALIAS
lncND
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 129787
MIM: 613220
HGNC: 25257
Ensembl: ENSG00000151353

Variants:

dbSNP: 129787
ClinVar: 129787
TCGA: ENSG00000151353
COSMIC: TMEM18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151353ENST00000281017Q96B42
ENSG00000151353ENST00000355654Q96B42
ENSG00000151353ENST00000405941B5MBX8
ENSG00000151353ENST00000418447F8WEA7
ENSG00000151353ENST00000432667F8WBA6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190792612009Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.700
204219362010Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.125
191643862009Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.104
196924902009Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference.77
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
198121712010Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.74
205208482010Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.70
207245812010Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.47
202153972010Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.44
208161952010Analyses of shared genetic factors between asthma and obesity in children.43

Citation

Dessen P

TMEM18 (transmembrane protein 18)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53977/tmem18