TMEM8B (transmembrane protein 8B)

2009-06-01  

Identity

HGNC
TMEM8B
LOCATION
9p13.3
LOCUSID
51754
ALIAS
C9orf127,FP588,LINC00950,NAG-5,NAG5,NGX6,NGX6a

Other Information

Locus ID:

NCBI: 51754
MIM: 616888
HGNC: 21427
Ensembl: ENSG00000137103

Variants:

dbSNP: 51754
ClinVar: 51754
TCGA: ENSG00000137103
COSMIC: TMEM8B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137103ENST00000377988A6NDV4
ENSG00000137103ENST00000377991A6NDV4
ENSG00000137103ENST00000377996A6NDV4
ENSG00000137103ENST00000439587A6NDV4
ENSG00000137103ENST00000643932A0A2R8Y2M5
ENSG00000137103ENST00000650015A6NDV4

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208597562010Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells.23
154987892005Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells.12
129181092003Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer.11
230539532012Evaluation of UDP-glucuronosyltransferase 2B17 (UGT2B17) and dihydrofolate reductase (DHFR) genes deletion and the expression level of NGX6 mRNA in breast cancer.11
176415382006The role of NGX6 and its deletion mutants in the proliferation, adhesion and migration of nasopharyngeal carcinoma 5-8F cells.9
194991542009NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human colorectal cancer.8
204234732010NGX6 gene mediated by promoter methylation as a potential molecular marker in colorectal cancer.8
207055832010NGX6 inhibits cell invasion and adhesion through suppression of Wnt/beta-catenin signal pathway in colon cancer.7
250299112014Egr-1 regulates the transcription of NGX6 gene through a Sp1/Egr-1 overlapping site in the promoter.5
243382742014DNA promoter and histone H3 methylation downregulate NGX6 in gastric cancer cells.4

Citation

Dessen P

TMEM8B (transmembrane protein 8B)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50966/tmem8b