TMOD1 (tropomodulin 1)

2007-02-01  

Identity

HGNC
LOCATION
9q22.33
LOCUSID
ALIAS
D9S57E,ETMOD,TMOD
FUSION GENES

Other Information

Locus ID:

NCBI: 7111
MIM: 190930
HGNC: 11871
Ensembl: ENSG00000136842

Variants:

dbSNP: 7111
ClinVar: 7111
TCGA: ENSG00000136842
COSMIC: TMOD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136842ENST00000259365P28289
ENSG00000136842ENST00000375175P28289
ENSG00000136842ENST00000395211P28289

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Striated Muscle ContractionREACTOMER-HSA-390522

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
250612122014Mechanism of actin filament pointed-end capping by tropomodulin.45
119642452002Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin.26
150953012004Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder.18
164343952006Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres.10
253984402015Tropomodulin 1 expression driven by NF-κB enhances breast cancer growth.8
268732452016Localization of the binding interface between leiomodin-2 and α-tropomyosin.8
249223512014Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3.7
287294322017Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome.7
162973722005Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction.5

Citation

Dessen P

TMOD1 (tropomodulin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43775/tmod1