TMPRSS11D (transmembrane serine protease 11D)

2016-08-01  

Identity

HGNC
TMPRSS11D
LOCATION
4q13.2
LOCUSID
9407
ALIAS
ASP,HAT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9407
MIM: 605369
HGNC: 24059
Ensembl: ENSG00000153802

Variants:

dbSNP: 9407
ClinVar: 9407
TCGA: ENSG00000153802
COSMIC: TMPRSS11D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153802ENST00000283916O60235
ENSG00000153802ENST00000514868H0Y8K7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
169735942006Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium.164
219944422011Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease.84
225582512012Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.77
231928722013Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses.47
161994372006Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway.22
151020842004Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris.18
163362752005Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells.18
220238012012Hepatocyte growth factor activator inhibitor type 1 inhibits protease activity and proteolytic activation of human airway trypsin-like protease.16
126305742003Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells.15
262978352016Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis.6

Citation

Dessen P

TMPRSS11D (transmembrane serine protease 11D)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55889/tmprss11d