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TMPRSS2 (transmembrane protease, serine 2)

Identity

Other namesFLJ41954
PP9284
PRSS10
HGNC (Hugo) TMPRSS2
Location 21q22.3
Location_base_pair Starts at 41758350 and ends at 41801955 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 

External links

Nomenclature
HGNC (Hugo)TMPRSS2   11876
Entrez_Gene (NCBI)TMPRSS2  7113  transmembrane protease, serine 2
Cards
GeneCards (Weizmann)TMPRSS2
Ensembl (Hinxton)ENSG00000184012 [Gene_View]  TMPRSS2 [Vega]
AceView (NCBI)TMPRSS2
Genatlas (Paris)TMPRSS2
euGene (Indiana)7113
SOURCE (Stanford)NM_001135099 NM_005656
Gene Expression (Array Express) ENSG00000184012
Genomic and cartography
GoldenPath (UCSC)TMPRSS2  -  21q22.3   chr21:41758350-41801955 -  21q22.3   [Description]    (hg18-March_2006)
EnsemblTMPRSS2 - 21q22.3 [CytoView]
Mapping of homologs : NCBITMPRSS2 [Mapview]
OMIM602060   
Gene and transcription
Gene : Genbank (Entrez)AA904080 AF123453 AF270487 AF318374 AF329454
Reference sequence (RefSeq transcript) :SRSNM_001135099 NM_005656
Reference transcript : EntrezNM_001135099 NM_005656
RefSeq genomic : SRSAC_000064 AC_000153 NC_000021 NT_011512 NW_001838710 NW_927384
RefSeq genomic : EntrezAC_000064 AC_000153 NC_000021 NT_011512 NW_001838710 NW_927384
Consensus coding sequences : CCDS NCBITMPRSS2
Cluster EST : UnigeneHs.439309 [ SRS ] Hs.439309 [ NCBI ]
Alternative Splicing : Fast-db (Paris)3123
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtO15393 (SRS) O15393 (Expasy) O15393 (Uniprot)
With graphics : InterProO15393
Splice isoforms : VarSplice FASTAO15393(VarSplice FASTA)
Domaine pattern : Prosite (SRS)LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    SRCR_1 (PS00420)    SRCR_2 (PS50287)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domain pattern : Prosite (Expaxy)LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    SRCR_1 (PS00420)    SRCR_2 (PS50287)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (SRS)LDL_rcpt_classA_cys-rich_rpt    Peptidase_S1/S6_AS    Peptidase_S1_S6    Peptidase_S1A    Ser/Cys_Pept_Trypsin-like    Srcr_rcpt    Srcr_rcpt-rel   
Domains : Interpro (EBI)LDL_rcpt_classA_cys-rich_rpt    Peptidase_S1/S6_AS    Peptidase_S1_S6    Peptidase_S1A    Ser/Cys_Pept_Trypsin-like    Srcr_rcpt    Srcr_rcpt-rel   
Related proteins : CluSTrO15393
Domain families : Pfam SRSSRCR (PF00530)    Trypsin (PF00089)   
Domain families : Pfam SangerSRCR (PF00530)    Trypsin (PF00089)   
Domain families : Pfam NCBIpfam00530    pfam00089   
Domain families : Smart EMBLLDLa (SM00192)  SR (SM00202)  Tryp_SPc (SM00020)  
Blocks (Seattle)O15393
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD03637
Protein Interaction databases
DIP (DOE-UCLA)O15393
IntAct (EBI)O15393
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBITMPRSS2
SNP : GeneSNP UtahTMPRSS2
SNP : HGBaseTMPRSS2
Genetic variants : HAPMAPTMPRSS2
Cancer Gene: CensusTMPRSS2 
Somatic Mutations in Cancer : COSMICTMPRSS2 
Rearrangement : COSMICTMPRSS2 21q22.3  -  ERG 21q22.2
Rearrangement : COSMICTMPRSS2 21q22.3  -  ETV1 7p21.2
Translocation Breakpoints in Cancer : TICdbserine-type 
Mutations and Diseases : HGMDTMPRSS2
Hereditary diseases : OMIM602060   
Hereditary diseases : GENETests602060   
Diseases : Genetic AssociationTMPRSS2
General knowledge
Homologs : HomoloGeneTMPRSS2
Homology/Alignments : Family Browser UCSCTMPRSS2
Phylogenetic Trees/Animal Genes : TreeFamTMPRSS2
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.- [ Enzyme-SRS ]   3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
Chemical/Protein Interactions : CTD7113
Keywords Ontology : AmiGOserine-type endopeptidase activity  scavenger receptor activity  extracellular region  cytoplasm  plasma membrane  integral to plasma membrane  proteolysis  peptidase activity  
Keywords Ontology : EGO-EBIserine-type endopeptidase activity  scavenger receptor activity  extracellular region  cytoplasm  plasma membrane  integral to plasma membrane  proteolysis  peptidase activity  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesTMPRSS2 Related clones (RZPD - Berlin)
Literature
PubMed49 Pubmed reference(s) in Entrez
PubGeneTMPRSS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:37:41 CET 2010
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