TMSB4X (thymosin beta 4 X-linked)

2003-02-01  

Identity

HGNC
TMSB4X
LOCATION
Xp22.2
LOCUSID
7114
ALIAS
FX,PTMB4,TB4X,TMSB4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7114
MIM: 300159
HGNC: 11881
Ensembl: ENSG00000205542

Variants:

dbSNP: 7114
ClinVar: 7114
TCGA: ENSG00000205542
COSMIC: TMSB4X

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205542ENST00000380633P62328
ENSG00000205542ENST00000380633A2VCK8
ENSG00000205542ENST00000380635P62328
ENSG00000205542ENST00000380635A2VCK8
ENSG00000205542ENST00000380636P62328
ENSG00000205542ENST00000380636A2VCK8
ENSG00000205542ENST00000451311P62328
ENSG00000205542ENST00000451311A2VCK8

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
7000
8000
9000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
152355862004Overexpression of the thymosin beta-4 gene is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinoma.26
154668842004Nuclear localisation of the G-actin sequestering peptide thymosin beta4.23
165157842006ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistance.19
253130622014Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization.19
206912192010Thymosin β4 induces the expression of vascular endothelial growth factor (VEGF) in a hypoxia-inducible factor (HIF)-1α-dependent manner.16
215144252011Thymosin-β4 (Tβ4) blunts PDGF-dependent phosphorylation and binding of AKT to actin in hepatic stellate cells.16
211069362011Regenerative protein thymosin beta-4 is a novel regulator of purinergic signaling.15
274696252016The TMSB4 Pseudogene LncRNA Functions as a Competing Endogenous RNA to Promote Cartilage Degradation in Human Osteoarthritis.14
223285342012Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration.13
176002852007Identification and quantification of thymosin beta4 in human saliva and tears.12

Citation

Dessen P

TMSB4X (thymosin beta 4 X-linked)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42596/tmsb4x