TMX3 (thioredoxin related transmembrane protein 3)

2021-06-01  

Identity

HGNC
LOCATION
18q22.1
LOCUSID
ALIAS
PDIA13,TXNDC10

Other Information

Locus ID:

NCBI: 54495
MIM: 616102
HGNC: 24718
Ensembl: ENSG00000166479

Variants:

dbSNP: 54495
ClinVar: 54495
TCGA: ENSG00000166479
COSMIC: TMX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166479ENST00000299608Q96JJ7
ENSG00000166479ENST00000443099B4DIE3
ENSG00000166479ENST00000562706Q96JJ7
ENSG00000166479ENST00000564008H3BRY0
ENSG00000166479ENST00000564631H3BVI1
ENSG00000166479ENST00000565918H3BPB3
ENSG00000166479ENST00000569053H3BVI1
ENSG00000166479ENST00000569982H3BT89

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
156235052005Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum.33
204855072010A male with unilateral microphthalmia reveals a role for TMX3 in eye development.16
178813532007Structure-function analysis of the endoplasmic reticulum oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain.8
313049842019Redox signals at the ER-mitochondria interface control melanoma progression.4

Citation

Dessen P

TMX3 (thioredoxin related transmembrane protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58181/tmx3