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TNFAIP8 (TNF alpha induced protein 8)

Identity

Alias_namestumor necrosis factor, alpha-induced protein 8
Alias_symbol (synonym)GG2-1
MDC-3.13
SCC-S2
Other aliasNDED
SCCS2
HGNC (Hugo) TNFAIP8
LocusID (NCBI) 25816
Atlas_Id 42604
Location 5q23.1  [Link to chromosome band 5q23]
Location_base_pair Starts at 119355820 and ends at 119394604 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACBD4 (17q21.31) / TNFAIP8 (5q23.1)IPO11 (5q12.1) / TNFAIP8 (5q23.1)MOB2 (11p15.5) / TNFAIP8 (5q23.1)
TNFAIP8 (5q23.1) / NRXN3 (14q31.1)TNFAIP8 (5q23.1) / SCARB2 (4q21.1)TNFAIP8 (5q23.1) / TMEM216 (11q12.2)
TNFAIP8 (5q23.1) / TNFAIP8 (5q23.1)IPO11 5q12.1 / TNFAIP8 5q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;5)(q12;q23) IPO11/TNFAIP8

External links

Nomenclature
HGNC (Hugo)TNFAIP8   17260
Cards
Entrez_Gene (NCBI)TNFAIP8  25816  TNF alpha induced protein 8
AliasesGG2-1; MDC-3.13; NDED; SCC-S2; 
SCCS2
GeneCards (Weizmann)TNFAIP8
Ensembl hg19 (Hinxton)ENSG00000145779 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145779 [Gene_View]  ENSG00000145779 [Sequence]  chr5:119355820-119394604 [Contig_View]  TNFAIP8 [Vega]
ICGC DataPortalENSG00000145779
TCGA cBioPortalTNFAIP8
AceView (NCBI)TNFAIP8
Genatlas (Paris)TNFAIP8
WikiGenes25816
SOURCE (Princeton)TNFAIP8
Genetics Home Reference (NIH)TNFAIP8
Genomic and cartography
GoldenPath hg38 (UCSC)TNFAIP8  -     chr5:119355820-119394604 +  5q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFAIP8  -     5q23.1   [Description]    (hg19-Feb_2009)
GoldenPathTNFAIP8 - 5q23.1 [CytoView hg19]  TNFAIP8 - 5q23.1 [CytoView hg38]
ImmunoBaseENSG00000145779
Mapping of homologs : NCBITNFAIP8 [Mapview hg19]  TNFAIP8 [Mapview hg38]
OMIM612111   
Gene and transcription
Genbank (Entrez)AF070671 AF098933 AF098934 AF099935 AF099936
RefSeq transcript (Entrez)NM_001077654 NM_001286813 NM_001286814 NM_001286815 NM_001286817 NM_014350
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFAIP8
Cluster EST : UnigeneHs.656274 [ NCBI ]
CGAP (NCI)Hs.656274
Alternative Splicing GalleryENSG00000145779
Gene ExpressionTNFAIP8 [ NCBI-GEO ]   TNFAIP8 [ EBI - ARRAY_EXPRESS ]   TNFAIP8 [ SEEK ]   TNFAIP8 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFAIP8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25816
GTEX Portal (Tissue expression)TNFAIP8
Human Protein AtlasENSG00000145779-TNFAIP8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95379   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95379  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95379
Splice isoforms : SwissVarO95379
PhosPhoSitePlusO95379
Domains : Interpro (EBI)TNFAIP8-like    TNFAIP8_sf   
Domain families : Pfam (Sanger)DUF758 (PF05527)   
Domain families : Pfam (NCBI)pfam05527   
Conserved Domain (NCBI)TNFAIP8
DMDM Disease mutations25816
Blocks (Seattle)TNFAIP8
SuperfamilyO95379
Human Protein Atlas [tissue]ENSG00000145779-TNFAIP8 [tissue]
Peptide AtlasO95379
HPRD18204
IPIIPI00027627   IPI00807579   IPI00965827   IPI00965514   IPI00966585   IPI00845242   
Protein Interaction databases
DIP (DOE-UCLA)O95379
IntAct (EBI)O95379
FunCoupENSG00000145779
BioGRIDTNFAIP8
STRING (EMBL)TNFAIP8
ZODIACTNFAIP8
Ontologies - Pathways
QuickGOO95379
Ontology : AmiGOprotein binding  nucleoplasm  cytoplasm  cytoplasm  apoptotic process  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  
Ontology : EGO-EBIprotein binding  nucleoplasm  cytoplasm  cytoplasm  apoptotic process  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  
NDEx NetworkTNFAIP8
Atlas of Cancer Signalling NetworkTNFAIP8
Wikipedia pathwaysTNFAIP8
Orthology - Evolution
OrthoDB25816
GeneTree (enSembl)ENSG00000145779
Phylogenetic Trees/Animal Genes : TreeFamTNFAIP8
HOGENOMO95379
Homologs : HomoloGeneTNFAIP8
Homology/Alignments : Family Browser (UCSC)TNFAIP8
Gene fusions - Rearrangements
Fusion : MitelmanIPO11/TNFAIP8 [5q12.1/5q23.1]  [t(5;5)(q12;q23)]  
Fusion PortalIPO11 5q12.1 TNFAIP8 5q23.1 BRCA
Fusion : QuiverTNFAIP8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFAIP8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFAIP8
dbVarTNFAIP8
ClinVarTNFAIP8
1000_GenomesTNFAIP8 
Exome Variant ServerTNFAIP8
ExAC (Exome Aggregation Consortium)ENSG00000145779
GNOMAD BrowserENSG00000145779
Varsome BrowserTNFAIP8
Genetic variants : HAPMAP25816
Genomic Variants (DGV)TNFAIP8 [DGVbeta]
DECIPHERTNFAIP8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFAIP8 
Mutations
ICGC Data PortalTNFAIP8 
TCGA Data PortalTNFAIP8 
Broad Tumor PortalTNFAIP8
OASIS PortalTNFAIP8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFAIP8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFAIP8
Mutations and Diseases : HGMDTNFAIP8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFAIP8
DgiDB (Drug Gene Interaction Database)TNFAIP8
DoCM (Curated mutations)TNFAIP8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFAIP8 (select a term)
intoGenTNFAIP8
Cancer3DTNFAIP8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612111   
Orphanet
DisGeNETTNFAIP8
MedgenTNFAIP8
Genetic Testing Registry TNFAIP8
NextProtO95379 [Medical]
TSGene25816
GENETestsTNFAIP8
Target ValidationTNFAIP8
Huge Navigator TNFAIP8 [HugePedia]
snp3D : Map Gene to Disease25816
BioCentury BCIQTNFAIP8
ClinGenTNFAIP8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25816
Chemical/Pharm GKB GenePA134957136
Clinical trialTNFAIP8
Miscellaneous
canSAR (ICR)TNFAIP8 (select the gene name)
DataMed IndexTNFAIP8
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFAIP8
EVEXTNFAIP8
GoPubMedTNFAIP8
iHOPTNFAIP8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:12:20 CET 2019
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