TNFAIP8L2 (TNF alpha induced protein 8 like 2)

2005-11-01  

Identity

HGNC
TNFAIP8L2
LOCATION
1q21.3
LOCUSID
79626
ALIAS
TIPE2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79626
MIM: 612112
HGNC: 26277
Ensembl: ENSG00000163154

Variants:

dbSNP: 79626
ClinVar: 79626
TCGA: ENSG00000163154
COSMIC: TNFAIP8L2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163154ENST00000368910Q6P589

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255

References

Pubmed IDYearTitleCitations
223260552012The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras.43
214668952011Roles of TIPE2 in hepatitis B virus-induced hepatic inflammation in humans and mice.33
242745782013Human tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 suppresses hepatocellular carcinoma metastasis through inhibiting Rac1.25
206635612010Tissue-specific expression of TIPE2 provides insights into its function.22
214594482011The unique expression profile of human TIPE2 suggests new functions beyond its role in immune regulation.22
253392672015TIPE2 inhibits TNF-α-induced hepatocellular carcinoma cell metastasis via Erk1/2 downregulation and NF-κB activation.16
255364472015Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) upregulates p27 to decrease gastic cancer cell proliferation.15
259461862015TIPE2 Inhibits Lung Cancer Growth Attributing to Promotion of Apoptosis by Regulating Some Apoptotic Molecules Expression.15
248064462014TIPE2 negatively regulates inflammation by switching arginine metabolism from nitric oxide synthase to arginase.14
275566982016TIPE2 suppresses angiogenesis and non-small cell lung cancer (NSCLC) invasiveness via inhibiting Rac1 activation and VEGF expression.14

Citation

Dessen P

TNFAIP8L2 (TNF alpha induced protein 8 like 2)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43043/tnfaip8l2