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TNFAIP8L3 (TNF alpha induced protein 8 like 3)

Identity

Alias_namestumor necrosis factor, alpha-induced protein 8-like 3
Alias_symbol (synonym)FLJ41287
Other aliasTIPE3
HGNC (Hugo) TNFAIP8L3
LocusID (NCBI) 388121
Atlas_Id 43044
Location 15q21.2  [Link to chromosome band 15q21]
Location_base_pair Starts at 51056601 and ends at 51105276 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARNT2 (15q25.1) / TNFAIP8L3 (15q21.2)ARNT2 15q25.1 / TNFAIP8L3 15q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(15;15)(q21;q25) ARNT2/TNFAIP8L3

External links

Nomenclature
HGNC (Hugo)TNFAIP8L3   20620
Cards
Entrez_Gene (NCBI)TNFAIP8L3  388121  TNF alpha induced protein 8 like 3
AliasesTIPE3
GeneCards (Weizmann)TNFAIP8L3
Ensembl hg19 (Hinxton)ENSG00000183578 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183578 [Gene_View]  ENSG00000183578 [Sequence]  chr15:51056601-51105276 [Contig_View]  TNFAIP8L3 [Vega]
ICGC DataPortalENSG00000183578
TCGA cBioPortalTNFAIP8L3
AceView (NCBI)TNFAIP8L3
Genatlas (Paris)TNFAIP8L3
WikiGenes388121
SOURCE (Princeton)TNFAIP8L3
Genetics Home Reference (NIH)TNFAIP8L3
Genomic and cartography
GoldenPath hg38 (UCSC)TNFAIP8L3  -     chr15:51056601-51105276 -  15q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFAIP8L3  -     15q21.2   [Description]    (hg19-Feb_2009)
GoldenPathTNFAIP8L3 - 15q21.2 [CytoView hg19]  TNFAIP8L3 - 15q21.2 [CytoView hg38]
ImmunoBaseENSG00000183578
Mapping of homologs : NCBITNFAIP8L3 [Mapview hg19]  TNFAIP8L3 [Mapview hg38]
OMIM616438   
Gene and transcription
Genbank (Entrez)AK123281 AY517501 BC127701 BC127702 CA447540
RefSeq transcript (Entrez)NM_001311175 NM_207381
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFAIP8L3
Cluster EST : UnigeneHs.306343 [ NCBI ]
CGAP (NCI)Hs.306343
Alternative Splicing GalleryENSG00000183578
Gene ExpressionTNFAIP8L3 [ NCBI-GEO ]   TNFAIP8L3 [ EBI - ARRAY_EXPRESS ]   TNFAIP8L3 [ SEEK ]   TNFAIP8L3 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFAIP8L3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)388121
GTEX Portal (Tissue expression)TNFAIP8L3
Human Protein AtlasENSG00000183578-TNFAIP8L3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5GJ75   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5GJ75  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5GJ75
Splice isoforms : SwissVarQ5GJ75
PhosPhoSitePlusQ5GJ75
Domains : Interpro (EBI)TNFAIP8-like    TNFAIP8_sf   
Domain families : Pfam (Sanger)DUF758 (PF05527)   
Domain families : Pfam (NCBI)pfam05527   
Conserved Domain (NCBI)TNFAIP8L3
DMDM Disease mutations388121
Blocks (Seattle)TNFAIP8L3
PDB (RSDB)4Q9V   
PDB Europe4Q9V   
PDB (PDBSum)4Q9V   
PDB (IMB)4Q9V   
Structural Biology KnowledgeBase4Q9V   
SCOP (Structural Classification of Proteins)4Q9V   
CATH (Classification of proteins structures)4Q9V   
SuperfamilyQ5GJ75
Human Protein Atlas [tissue]ENSG00000183578-TNFAIP8L3 [tissue]
Peptide AtlasQ5GJ75
HPRD13452
IPIIPI00399076   
Protein Interaction databases
DIP (DOE-UCLA)Q5GJ75
IntAct (EBI)Q5GJ75
FunCoupENSG00000183578
BioGRIDTNFAIP8L3
STRING (EMBL)TNFAIP8L3
ZODIACTNFAIP8L3
Ontologies - Pathways
QuickGOQ5GJ75
Ontology : AmiGOnucleoplasm  cytoplasm  cytoplasm  cytosol  cytosol  plasma membrane  phospholipid metabolic process  phosphatidylinositol transporter activity  phospholipid transport  regulation of lipid metabolic process  phosphatidylinositol binding  regulation of apoptotic process  positive regulation of phosphatidylinositol 3-kinase activity  inositol lipid-mediated signaling  positive regulation of protein kinase B signaling  positive regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBInucleoplasm  cytoplasm  cytoplasm  cytosol  cytosol  plasma membrane  phospholipid metabolic process  phosphatidylinositol transporter activity  phospholipid transport  regulation of lipid metabolic process  phosphatidylinositol binding  regulation of apoptotic process  positive regulation of phosphatidylinositol 3-kinase activity  inositol lipid-mediated signaling  positive regulation of protein kinase B signaling  positive regulation of ERK1 and ERK2 cascade  
NDEx NetworkTNFAIP8L3
Atlas of Cancer Signalling NetworkTNFAIP8L3
Wikipedia pathwaysTNFAIP8L3
Orthology - Evolution
OrthoDB388121
GeneTree (enSembl)ENSG00000183578
Phylogenetic Trees/Animal Genes : TreeFamTNFAIP8L3
HOGENOMQ5GJ75
Homologs : HomoloGeneTNFAIP8L3
Homology/Alignments : Family Browser (UCSC)TNFAIP8L3
Gene fusions - Rearrangements
Fusion : MitelmanARNT2/TNFAIP8L3 [15q25.1/15q21.2]  [t(15;15)(q21;q25)]  
Fusion PortalARNT2 15q25.1 TNFAIP8L3 15q21.2 KIRC
Fusion : QuiverTNFAIP8L3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFAIP8L3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFAIP8L3
dbVarTNFAIP8L3
ClinVarTNFAIP8L3
1000_GenomesTNFAIP8L3 
Exome Variant ServerTNFAIP8L3
ExAC (Exome Aggregation Consortium)ENSG00000183578
GNOMAD BrowserENSG00000183578
Varsome BrowserTNFAIP8L3
Genetic variants : HAPMAP388121
Genomic Variants (DGV)TNFAIP8L3 [DGVbeta]
DECIPHERTNFAIP8L3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFAIP8L3 
Mutations
ICGC Data PortalTNFAIP8L3 
TCGA Data PortalTNFAIP8L3 
Broad Tumor PortalTNFAIP8L3
OASIS PortalTNFAIP8L3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFAIP8L3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFAIP8L3
Mutations and Diseases : HGMDTNFAIP8L3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFAIP8L3
DgiDB (Drug Gene Interaction Database)TNFAIP8L3
DoCM (Curated mutations)TNFAIP8L3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFAIP8L3 (select a term)
intoGenTNFAIP8L3
Cancer3DTNFAIP8L3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616438   
Orphanet
DisGeNETTNFAIP8L3
MedgenTNFAIP8L3
Genetic Testing Registry TNFAIP8L3
NextProtQ5GJ75 [Medical]
TSGene388121
GENETestsTNFAIP8L3
Target ValidationTNFAIP8L3
Huge Navigator TNFAIP8L3 [HugePedia]
snp3D : Map Gene to Disease388121
BioCentury BCIQTNFAIP8L3
ClinGenTNFAIP8L3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD388121
Chemical/Pharm GKB GenePA142670724
Clinical trialTNFAIP8L3
Miscellaneous
canSAR (ICR)TNFAIP8L3 (select the gene name)
DataMed IndexTNFAIP8L3
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFAIP8L3
EVEXTNFAIP8L3
GoPubMedTNFAIP8L3
iHOPTNFAIP8L3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:12:21 CET 2019
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