Identity
HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
APO2,CD261,DR4,TRAILR-1,TRAILR1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8797
MIM: 603611
HGNC: 11904
Ensembl: ENSG00000104689
Variants:
dbSNP: 8797
ClinVar: 8797
TCGA: ENSG00000104689
COSMIC: TNFRSF10A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000104689 | ENST00000221132 | O00220 |
| ENSG00000104689 | ENST00000524158 | E5RFH1 |
| ENSG00000104689 | ENST00000613472 | F8U8C0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation | associated | PD | 22480748 | |
| PA443430 | Arthritis | Disease | ClinicalAnnotation | associated | PD | 22480748 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33664875 | 2021 | Downregulation of death receptor 4 is tightly associated with positive response of EGFR mutant lung cancer to EGFR-targeted therapy and improved prognosis. | 10 |
| 34198757 | 2021 | Epigenetic Modification of Death Receptor Genes for TRAIL and TRAIL Resistance in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia. | 3 |
| 34275891 | 2021 | Genetic variations in tumor ecrosis factor related apoptosis-inducing ligand receptor-1 (TRAIL-R1) gene and the susceptibility to b-cell non-hodgkin lymphoma (B-NHL) in Egypt. | 0 |
| 34342264 | 2021 | Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization. | 22 |
| 35052395 | 2021 | Associations of Single-Nucleotide Polymorphisms in Slovenian Patients with Acute Central Serous Chorioretinopathy. | 2 |
| 33664875 | 2021 | Downregulation of death receptor 4 is tightly associated with positive response of EGFR mutant lung cancer to EGFR-targeted therapy and improved prognosis. | 10 |
| 34198757 | 2021 | Epigenetic Modification of Death Receptor Genes for TRAIL and TRAIL Resistance in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia. | 3 |
| 34275891 | 2021 | Genetic variations in tumor ecrosis factor related apoptosis-inducing ligand receptor-1 (TRAIL-R1) gene and the susceptibility to b-cell non-hodgkin lymphoma (B-NHL) in Egypt. | 0 |
| 34342264 | 2021 | Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization. | 22 |
| 35052395 | 2021 | Associations of Single-Nucleotide Polymorphisms in Slovenian Patients with Acute Central Serous Chorioretinopathy. | 2 |
| 31094932 | 2020 | TNF-Related Apoptosis-Inducing Ligand Receptor 1 in Patients With Ankylosing Spondylitis. | 2 |
| 32342239 | 2020 | The Impact of TRAIL (C1595T and G1525A) and DR4 (rs20576) Gene Polymorphisms on Systemic Lupus Erythematosus. | 0 |
| 32692906 | 2020 | O-glycans on death receptors in cells modulate their sensitivity to TRAIL-induced apoptosis through affecting on their stability and oligomerization. | 18 |
| 33269432 | 2020 | TRAILR1 (rs20576) and GRIA3 (rs12557782) are not associated with interferon-β response in multiple sclerosis patients. | 0 |
| 31094932 | 2020 | TNF-Related Apoptosis-Inducing Ligand Receptor 1 in Patients With Ankylosing Spondylitis. | 2 |
Citation
Dessen P
TNFRSF10A (TNF receptor superfamily member 10a)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/42605/tnfrsf10a
