Identity
HGNC
LOCATION
18q21.33
LOCUSID
ALIAS
CD265,FEO,LOH18CR1,ODFR,OFE,OPTB7,OSTS,PDB2,RANK,TRANCE-R,TRANCER
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8792
MIM: 603499
HGNC: 11908
Ensembl: ENSG00000141655
Variants:
dbSNP: 8792
ClinVar: 8792
TCGA: ENSG00000141655
COSMIC: TNFRSF11A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713217 | Pyrazolones | Chemical | ClinicalAnnotation | associated | PD | 26398624 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA448015 | acetaminophen | Chemical | ClinicalAnnotation | associated | PD | 26398624 | |
| PA448497 | aspirin | Chemical | ClinicalAnnotation | associated | PD | 26398624 | |
| PA449293 | diclofenac | Chemical | ClinicalAnnotation | associated | PD | 26398624 | |
| PA451140 | propionic acid derivatives | Chemical | ClinicalAnnotation | associated | PD | 26398624 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36520195 | 2023 | Familial Paget's disease of bone with ocular manifestations and a novel TNFRSF11A duplication variant (72dup27). | 2 |
| 36535121 | 2023 | Assessment of RANK/RANK-L prevalence and clinical significance in NSCLC European Thoracic Oncology Platform Lungscape cohort and SPLENDOUR randomized clinical trial. | 0 |
| 36520195 | 2023 | Familial Paget's disease of bone with ocular manifestations and a novel TNFRSF11A duplication variant (72dup27). | 2 |
| 36535121 | 2023 | Assessment of RANK/RANK-L prevalence and clinical significance in NSCLC European Thoracic Oncology Platform Lungscape cohort and SPLENDOUR randomized clinical trial. | 0 |
| 33962883 | 2022 | Receptor Activator of NF Kappa B (RANK) Expression Indicates Favorable Prognosis in Patients with Muscle-invasive Bladder Cancer. | 0 |
| 35055157 | 2022 | Molecular Mechanisms Leading from Periodontal Disease to Cancer. | 13 |
| 35163671 | 2022 | Histological Grade and Tumor Stage Are Correlated with Expression of Receptor Activator of Nuclear Factor Kappa b (Rank) in Epithelial Ovarian Cancers. | 0 |
| 35463988 | 2022 | RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages. | 4 |
| 35993046 | 2022 | The Effect of Osteoprotectin (OPG)/Receptor Activator of Nuclear Factor-κB Ligand (RANKL)/Receptor Activator of Nuclear Factor-κB (RANK) Gene Methylation on Aortic Valve Calcified. | 0 |
| 36589815 | 2022 | The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies. | 12 |
| 33962883 | 2022 | Receptor Activator of NF Kappa B (RANK) Expression Indicates Favorable Prognosis in Patients with Muscle-invasive Bladder Cancer. | 0 |
| 35055157 | 2022 | Molecular Mechanisms Leading from Periodontal Disease to Cancer. | 13 |
| 35163671 | 2022 | Histological Grade and Tumor Stage Are Correlated with Expression of Receptor Activator of Nuclear Factor Kappa b (Rank) in Epithelial Ovarian Cancers. | 0 |
| 35463988 | 2022 | RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages. | 4 |
| 35993046 | 2022 | The Effect of Osteoprotectin (OPG)/Receptor Activator of Nuclear Factor-κB Ligand (RANKL)/Receptor Activator of Nuclear Factor-κB (RANK) Gene Methylation on Aortic Valve Calcified. | 0 |
Citation
Dessen P
TNFRSF11A (TNF receptor superfamily member 11a)
Atlas Genet Cytogenet Oncol Haematol. 2013-05-01
Online version: http://atlasgeneticsoncology.org/gene/53317/tnfrsf11a
