TNFRSF14 (TNF receptor superfamily member 14)

2003-06-01 Affiliation

Identity

HGNC

TNFRSF14

LOCATION

1p36.32

LOCUSID

8764

ALIAS

ATAR,CD270,HVEA,HVEM,LIGHTR,TR2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8764
MIM: 602746
HGNC: 11912
Ensembl: ENSG00000157873

Variants:

dbSNP: 8764
ClinVar: 8764
TCGA: ENSG00000157873
COSMIC: TNFRSF14

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000157873	ENST00000355716	Q92956
ENSG00000157873	ENST00000355716	A0A024R052
ENSG00000157873	ENST00000409119	B9A034
ENSG00000157873	ENST00000426449	F6UPZ7
ENSG00000157873	ENST00000434817	F6Q0M4
ENSG00000157873	ENST00000435221	F6Q0M4
ENSG00000157873	ENST00000451778	F6Q0M4
ENSG00000157873	ENST00000482602	A0A0D9SF52

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Costimulation by the CD28 family	REACTOME	R-HSA-388841
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
TNFs bind their physiological receptors	REACTOME	R-HSA-5669034

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
23470321	2013	Molecular mechanisms of T cell co-stimulation and co-inhibition.	693
18794853	2008	Common variants at CD40 and other loci confer risk of rheumatoid arthritis.	199
15568026	2005	B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator.	197
18193050	2008	CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator.	113
12915568	2003	Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry.	92
16131544	2005	Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway.	90
15647361	2005	A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator.	85
19110536	2009	Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.	82
19332782	2009	Unconventional ligand activation of herpesvirus entry mediator signals cell survival.	74
15110526	2004	Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus.	69

Citation

Dessen P

TNFRSF14 (TNF receptor superfamily member 14)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42615/tnfrsf14