TNFRSF19 (TNF receptor superfamily member 19)

2003-05-01  

Identity

HGNC
TNFRSF19
LOCATION
13q12.12
LOCUSID
55504
ALIAS
TAJ,TAJ-alpha,TRADE,TROY

Other Information

Locus ID:

NCBI: 55504
MIM: 606122
HGNC: 11915
Ensembl: ENSG00000127863

Variants:

dbSNP: 55504
ClinVar: 55504
TCGA: ENSG00000127863
COSMIC: TNFRSF19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127863ENST00000248484Q9NS68
ENSG00000127863ENST00000382258Q9NS68
ENSG00000127863ENST00000382258A0A024RDM5
ENSG00000127863ENST00000382263Q9NS68
ENSG00000127863ENST00000403372Q9NS68

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060

References

Pubmed IDYearTitleCitations
205121452010A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.133
205121452010A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.133
231421372013Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells.37
208810092010TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling.33
172390122007TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
246234482014β-catenin regulates NF-κB activity via TNFRSF19 in colorectal cancer cells.23
236995352013TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance.22
171873582007Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target.15
297355482018TNFRSF19 Inhibits TGFβ Signaling through Interaction with TGFβ Receptor Type I to Promote Tumorigenesis.12

Citation

Dessen P

TNFRSF19 (TNF receptor superfamily member 19)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42618/tnfrsf19