Identity
HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
CD120a,FPF,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR1,TNFR55,TNFR60,p55,p55-R,p60
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7132
MIM: 191190
HGNC: 11916
Ensembl: ENSG00000067182
Variants:
dbSNP: 7132
ClinVar: 7132
TCGA: ENSG00000067182
COSMIC: TNFRSF1A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10004 | adalimumab | Chemical | ClinicalAnnotation | associated | PD | 22480748 | |
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation | associated | PD | 22480748, 24776844, 25311255 | |
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 22480748, 25311255 | |
| PA443815 | Crohn Disease | Disease | ClinicalAnnotation | associated | PD | 24776844 | |
| PA446116 | Inflammatory Bowel Diseases | Disease | ClinicalAnnotation | associated | PD | 24776844 | |
| PA446198 | Arthritis, Psoriatic | Disease | ClinicalAnnotation | associated | PD | 22480748 | |
| PA449515 | etanercept | Chemical | ClinicalAnnotation | associated | PD | 22480748 | |
| PA452639 | infliximab | Chemical | ClinicalAnnotation | associated | PD | 22480748 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38382266 | 2024 | Progesterone modulates TNF receptors expression by Jurkat cells cultured with plasma from pregnant women with preeclampsia. | 0 |
| 38562920 | 2024 | Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement. | 0 |
| 38865403 | 2024 | Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients. | 0 |
| 38382266 | 2024 | Progesterone modulates TNF receptors expression by Jurkat cells cultured with plasma from pregnant women with preeclampsia. | 0 |
| 38562920 | 2024 | Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement. | 0 |
| 38865403 | 2024 | Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients. | 0 |
| 36479675 | 2023 | C-Reactive Protein, Interleukin-6, Trimethylamine-N-Oxide, Syndecan-1, Nitric Oxide, and Tumor Necrosis Factor Receptor-1 in Heart Failure with Preserved Versus Reduced Ejection Fraction: a Meta-Analysis. | 2 |
| 36508390 | 2023 | TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study. | 1 |
| 36752501 | 2023 | A novel TNFRSF1A mutation associated with TNF-receptor-associated periodic syndrome and its metabolic signature. | 1 |
| 36830631 | 2023 | Impact of Tumor Necrosis Factor Receptor 1 (TNFR1) Polymorphism on Dry Eye Disease. | 0 |
| 37470237 | 2023 | TNFRSF1A-pR92Q variant identifies a subset of patients more similar to systemic undifferentiated recurrent fever than TNF receptor-associated periodic syndrome. | 0 |
| 38186567 | 2023 | Identification of TNFRSF1A as a novel regulator of carfilzomib resistance in multiple myeloma. | 0 |
| 36479675 | 2023 | C-Reactive Protein, Interleukin-6, Trimethylamine-N-Oxide, Syndecan-1, Nitric Oxide, and Tumor Necrosis Factor Receptor-1 in Heart Failure with Preserved Versus Reduced Ejection Fraction: a Meta-Analysis. | 2 |
| 36508390 | 2023 | TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study. | 1 |
| 36752501 | 2023 | A novel TNFRSF1A mutation associated with TNF-receptor-associated periodic syndrome and its metabolic signature. | 1 |
Citation
Dessen P
TNFRSF1A (TNF receptor superfamily member 1A)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42620/tnfrsf1a
