TNFRSF25 (TNF receptor superfamily member 25)

2003-05-01  

Identity

HGNC
LOCATION
1p36.31
LOCUSID
ALIAS
APO-3,DDR3,DR3,GEF720,LARD,PLEKHG5,TNFRSF12,TR3,TRAMP,WSL-1,WSL-LR

Other Information

Locus ID:

NCBI: 8718
MIM: 603366
HGNC: 11910
Ensembl: ENSG00000215788

Variants:

dbSNP: 8718
ClinVar: 8718
TCGA: ENSG00000215788
COSMIC: TNFRSF25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000215788ENST00000348333Q93038
ENSG00000215788ENST00000351748Q93038
ENSG00000215788ENST00000351959Q93038
ENSG00000215788ENST00000356876Q93038
ENSG00000215788ENST00000377782Q93038
ENSG00000215788ENST00000414040Q93038
ENSG00000215788ENST00000480393A0A0C4DGF3
ENSG00000215788ENST00000481401K7EJY9
ENSG00000215788ENST00000485036Q93038
ENSG00000215788ENST00000502588Q93038
ENSG00000215788ENST00000502730Q93038
ENSG00000215788ENST00000510563Q93038
ENSG00000215788ENST00000647810A0A3B3ISD9

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

References

Pubmed IDYearTitleCitations
184113412008Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation.84
128829792003TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells.43
157606792005Involvement of TL1A and DR3 in induction of pro-inflammatory cytokines and matrix metalloproteinase-9 in atherogenesis.39
236581102013Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors.24
216720302011Upregulation and nuclear localization of TNF-like cytokine 1A (TL1A) and its receptors DR3 and DcR3 in psoriatic skin lesions.19
152414672004Death receptor 3 (DR3) gene duplication in a chromosome region 1p36.3: gene duplication is more prevalent in rheumatoid arthritis.17
128759622003Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants.15
220439002012Interleukin-32 enhances cytotoxic effect of natural killer cells to cancer cells via activation of death receptor 3.15
252697042015A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality.14
169861652006Death receptor-3 mediates apoptosis in human osteoblasts under narrowly regulated conditions.13

Citation

Dessen P

TNFRSF25 (TNF receptor superfamily member 25)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42625/tnfrsf25