Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNFRSF4 (TNF receptor superfamily member 4)

Identity

Alias_namesTXGP1L
tumor necrosis factor receptor superfamily, member 4
Alias_symbol (synonym)ACT35
OX40
CD134
Other aliasIMD16
HGNC (Hugo) TNFRSF4
LocusID (NCBI) 7293
Atlas_Id 42626
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1211326 and ends at 1214168 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNFRSF4   11918
Cards
Entrez_Gene (NCBI)TNFRSF4  7293  TNF receptor superfamily member 4
AliasesACT35; CD134; IMD16; OX40; 
TXGP1L
GeneCards (Weizmann)TNFRSF4
Ensembl hg19 (Hinxton)ENSG00000186827 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186827 [Gene_View]  ENSG00000186827 [Sequence]  chr1:1211326-1214168 [Contig_View]  TNFRSF4 [Vega]
ICGC DataPortalENSG00000186827
TCGA cBioPortalTNFRSF4
AceView (NCBI)TNFRSF4
Genatlas (Paris)TNFRSF4
WikiGenes7293
SOURCE (Princeton)TNFRSF4
Genetics Home Reference (NIH)TNFRSF4
Genomic and cartography
GoldenPath hg38 (UCSC)TNFRSF4  -     chr1:1211326-1214168 -  1p36.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFRSF4  -     1p36.33   [Description]    (hg19-Feb_2009)
GoldenPathTNFRSF4 - 1p36.33 [CytoView hg19]  TNFRSF4 - 1p36.33 [CytoView hg38]
ImmunoBaseENSG00000186827
Mapping of homologs : NCBITNFRSF4 [Mapview hg19]  TNFRSF4 [Mapview hg38]
OMIM600315   615593   
Gene and transcription
Genbank (Entrez)AW290885 AW293499 BC040257 BC105070 BC105072
RefSeq transcript (Entrez)NM_003327
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFRSF4
Cluster EST : UnigeneHs.129780 [ NCBI ]
CGAP (NCI)Hs.129780
Alternative Splicing GalleryENSG00000186827
Gene ExpressionTNFRSF4 [ NCBI-GEO ]   TNFRSF4 [ EBI - ARRAY_EXPRESS ]   TNFRSF4 [ SEEK ]   TNFRSF4 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7293
GTEX Portal (Tissue expression)TNFRSF4
Human Protein AtlasENSG00000186827-TNFRSF4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43489   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43489  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43489
Splice isoforms : SwissVarP43489
PhosPhoSitePlusP43489
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_4    TNFRSF4_N    Tyr-kin_ephrin_A/B_rcpt-like   
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)Ephrin_rec_like (SM01411)  TNFR (SM00208)  
Conserved Domain (NCBI)TNFRSF4
DMDM Disease mutations7293
Blocks (Seattle)TNFRSF4
PDB (RSDB)1D0A    2HEV    2HEY   
PDB Europe1D0A    2HEV    2HEY   
PDB (PDBSum)1D0A    2HEV    2HEY   
PDB (IMB)1D0A    2HEV    2HEY   
Structural Biology KnowledgeBase1D0A    2HEV    2HEY   
SCOP (Structural Classification of Proteins)1D0A    2HEV    2HEY   
CATH (Classification of proteins structures)1D0A    2HEV    2HEY   
SuperfamilyP43489
Human Protein Atlas [tissue]ENSG00000186827-TNFRSF4 [tissue]
Peptide AtlasP43489
HPRD02636
IPIIPI00018859   IPI00515079   
Protein Interaction databases
DIP (DOE-UCLA)P43489
IntAct (EBI)P43489
FunCoupENSG00000186827
BioGRIDTNFRSF4
STRING (EMBL)TNFRSF4
ZODIACTNFRSF4
Ontologies - Pathways
QuickGOP43489
Ontology : AmiGOvirus receptor activity  tumor necrosis factor-activated receptor activity  protein binding  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  external side of plasma membrane  cell surface  positive regulation of B cell proliferation  tumor necrosis factor-mediated signaling pathway  T cell proliferation  negative regulation of DNA-binding transcription factor activity  negative regulation of transcription, DNA-templated  viral entry into host cell  negative regulation of cytokine secretion  positive regulation of immunoglobulin secretion  
Ontology : EGO-EBIvirus receptor activity  tumor necrosis factor-activated receptor activity  protein binding  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  external side of plasma membrane  cell surface  positive regulation of B cell proliferation  tumor necrosis factor-mediated signaling pathway  T cell proliferation  negative regulation of DNA-binding transcription factor activity  negative regulation of transcription, DNA-templated  viral entry into host cell  negative regulation of cytokine secretion  positive regulation of immunoglobulin secretion  
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFRSF4
Atlas of Cancer Signalling NetworkTNFRSF4
Wikipedia pathwaysTNFRSF4
Orthology - Evolution
OrthoDB7293
GeneTree (enSembl)ENSG00000186827
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF4
HOGENOMP43489
Homologs : HomoloGeneTNFRSF4
Homology/Alignments : Family Browser (UCSC)TNFRSF4
Gene fusions - Rearrangements
Fusion : QuiverTNFRSF4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF4
dbVarTNFRSF4
ClinVarTNFRSF4
1000_GenomesTNFRSF4 
Exome Variant ServerTNFRSF4
ExAC (Exome Aggregation Consortium)ENSG00000186827
GNOMAD BrowserENSG00000186827
Varsome BrowserTNFRSF4
Genetic variants : HAPMAP7293
Genomic Variants (DGV)TNFRSF4 [DGVbeta]
DECIPHERTNFRSF4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFRSF4 
Mutations
ICGC Data PortalTNFRSF4 
TCGA Data PortalTNFRSF4 
Broad Tumor PortalTNFRSF4
OASIS PortalTNFRSF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFRSF4
Mutations and Diseases : HGMDTNFRSF4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFRSF4
DgiDB (Drug Gene Interaction Database)TNFRSF4
DoCM (Curated mutations)TNFRSF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF4 (select a term)
intoGenTNFRSF4
Cancer3DTNFRSF4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600315    615593   
Orphanet23233   
DisGeNETTNFRSF4
MedgenTNFRSF4
Genetic Testing Registry TNFRSF4
NextProtP43489 [Medical]
TSGene7293
GENETestsTNFRSF4
Target ValidationTNFRSF4
Huge Navigator TNFRSF4 [HugePedia]
snp3D : Map Gene to Disease7293
BioCentury BCIQTNFRSF4
ClinGenTNFRSF4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7293
Chemical/Pharm GKB GenePA36611
Clinical trialTNFRSF4
Miscellaneous
canSAR (ICR)TNFRSF4 (select the gene name)
DataMed IndexTNFRSF4
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFRSF4
EVEXTNFRSF4
GoPubMedTNFRSF4
iHOPTNFRSF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:12:25 CET 2019
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