TNFSF12 (TNF superfamily member 12)

2003-06-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
APO3L,DR3LG,TNLG4A,TWEAK
FUSION GENES

Other Information

Locus ID:

NCBI: 8742
MIM: 602695
HGNC: 11927
Ensembl: ENSG00000239697

Variants:

dbSNP: 8742
ClinVar: 8742
TCGA: ENSG00000239697
COSMIC: TNFSF12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000239697ENST00000293825O43508
ENSG00000239697ENST00000293825Q4ACW9
ENSG00000239697ENST00000322272C0H5Y4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186068502008TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.106
170186102006Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome.86
171244962006TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration.72
175486572007A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications.69
156111302005The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression.68
197857302009Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study.59
194736602009The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis.54
156818342005A soluble Fn14-Fc decoy receptor reduces infarct volume in a murine model of cerebral ischemia.52
124458282002Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells.49
124219892002The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells.47

Citation

Dessen P

TNFSF12 (TNF superfamily member 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42634/tnfsf12