TNFSF13B (TNF superfamily member 13b)

2003-06-01  

Identity

HGNC
TNFSF13B
LOCATION
13q33.3
LOCUSID
10673
ALIAS
BAFF,BLYS,CD257,DTL,TALL-1,TALL1,THANK,TNFSF20,TNLG7A,ZTNF4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10673
MIM: 603969
HGNC: 11929
Ensembl: ENSG00000102524

Variants:

dbSNP: 10673
ClinVar: 10673
TCGA: ENSG00000102524
COSMIC: TNFSF13B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102524ENST00000375887Q9Y275
ENSG00000102524ENST00000375887A0A0U5J7Q1
ENSG00000102524ENST00000430559Q9Y275
ENSG00000102524ENST00000542136Q9Y275

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalVariantAnnotationnot associatedPD
PA166114904belimumabChemicalLabelAnnotationassociated
PA443560Breast NeoplasmsDiseaseVariantAnnotationnot associatedPD
PA444773LeukopeniaDiseaseVariantAnnotationnot associatedPD
PA445113NeutropeniaDiseaseVariantAnnotationnot associatedPD
PA449165cyclophosphamideChemicalVariantAnnotationnot associatedPD
PA449476epirubicinChemicalVariantAnnotationnot associatedPD

References

Pubmed IDYearTitleCitations
121543592002DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL.357
115096922001BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.207
150706972004BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone.146
128654162003BAFF selectively enhances the survival of plasmablasts generated from human memory B cells.128
246164782014Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.121
191687882009Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease.118
169143242006BAFF, APRIL and their receptors: structure, function and signaling.116
146739982003B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations.113
165472272006HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors.109
179427542008TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts.99

Citation

Dessen P

TNFSF13B (TNF superfamily member 13b)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42636/tnfsf13b