TNMD (tenomodulin)

2016-10-01  

Identity

HGNC
TNMD
LOCATION
Xq22.1
LOCUSID
64102
ALIAS
BRICD4,CHM1L,TEM

Other Information

Locus ID:

NCBI: 64102
MIM: 300459
HGNC: 17757
Ensembl: ENSG00000000005

Variants:

dbSNP: 64102
ClinVar: 64102
TCGA: ENSG00000000005
COSMIC: TNMD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000000005ENST00000373031Q9H2S6

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
268801102016Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.25
196025612009Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss.19
188385622008Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis.17
285662512017Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load.12
174951832007Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.9
227008042012Differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin.8
189820162008The genetic variation in the tenomodulin gene is associated with serum total and LDL cholesterol in a body size-dependent manner.7
185806882008The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators--the Finnish Diabetes Prevention Study.6
235931732013Tenomodulin expression in the periodontal ligament enhances cellular adhesion.6
193813472009Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration.4

Citation

Dessen P

TNMD (tenomodulin)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56201/tnmd