TNS1 (tensin 1)

2003-11-01  

Identity

HGNC
TNS1
LOCATION
2q35
LOCUSID
7145
ALIAS
MST091,MST122,MST127,MSTP091,MSTP122,MSTP127,MXRA6,PPP1R155,TNS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7145
MIM: 600076
HGNC: 11973
Ensembl: ENSG00000079308

Variants:

dbSNP: 7145
ClinVar: 7145
TCGA: ENSG00000079308
COSMIC: TNS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079308ENST00000171887Q9HBL0
ENSG00000079308ENST00000310858Q9HBL0
ENSG00000079308ENST00000413280C9JI43
ENSG00000079308ENST00000413554E7EMG1
ENSG00000079308ENST00000419504E9PF55
ENSG00000079308ENST00000423413C9J8K5
ENSG00000079308ENST00000430930E9PGF5
ENSG00000079308ENST00000439083C9JFT7
ENSG00000079308ENST00000446688H0Y4U1
ENSG00000079308ENST00000446903E7ERH1
ENSG00000079308ENST00000449814C9JZT0
ENSG00000079308ENST00000453356H7C3Z4
ENSG00000079308ENST00000611415E9PF55
ENSG00000079308ENST00000615025A0A087WWW7
ENSG00000079308ENST00000646520A0A2R8Y4T1
ENSG00000079308ENST00000649572A0A3B3IRK7
ENSG00000079308ENST00000651849A0A494C067

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
200108342010Genome-wide association study identifies five loci associated with lung function.230
200108342010Genome-wide association study identifies five loci associated with lung function.230
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
219650142011Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function.58
191945072009Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer.22
169534262006Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations.16
198260012009Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion.16
269491252016MicroRNA-548j functions as a metastasis promoter in human breast cancer by targeting Tensin1.15
207983942010Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK.14
293484582018Hic-5 regulates fibrillar adhesion formation to control tumor extracellular matrix remodeling through interaction with tensin1.10

Citation

Dessen P

TNS1 (tensin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42650/tns1