TNS2 (tensin 2)

2009-04-01  

Identity

HGNC
TNS2
LOCATION
12q13.13
LOCUSID
23371
ALIAS
C1-TEN,C1TEN,TENC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23371
MIM: 607717
HGNC: 19737
Ensembl: ENSG00000111077

Variants:

dbSNP: 23371
ClinVar: 23371
TCGA: ENSG00000111077
COSMIC: TNS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111077ENST00000314250Q63HR2
ENSG00000111077ENST00000314276Q63HR2
ENSG00000111077ENST00000379902Q63HR2
ENSG00000111077ENST00000379902A0A024RB48
ENSG00000111077ENST00000546602Q63HR2
ENSG00000111077ENST00000546772H0YID7
ENSG00000111077ENST00000549700F8VV64
ENSG00000111077ENST00000552570Q63HR2
ENSG00000111077ENST00000602335R4GMX1

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
158176392005C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration.38
124706482002Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.34
194403892009Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function.25
191945072009Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer.22
200695722010Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1.18
215278312011Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling.13
206784862010Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane.11
170069242006Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma.9
197475642010Individual domains of Tensin2 exhibit distinct subcellular localisations and migratory effects.8
198958402010START-GAP1/DLC1 is localized in focal adhesions through interaction with the PTB domain of tensin2.7

Citation

Dessen P

TNS2 (tensin 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-04-01

Online version: http://atlasgeneticsoncology.org/gene/50833/tns2