TNS3 (tensin 3)

2003-06-01  

Identity

HGNC
LOCATION
7p12.3
LOCUSID
ALIAS
TEM6,TENS1
FUSION GENES

Other Information

Locus ID:

NCBI: 64759
MIM: 606825
HGNC: 21616
Ensembl: ENSG00000136205

Variants:

dbSNP: 64759
ClinVar: 64759
TCGA: ENSG00000136205
COSMIC: TNS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136205ENST00000311160Q68CZ2
ENSG00000136205ENST00000413551C9JWN9
ENSG00000136205ENST00000415929C9JTD0
ENSG00000136205ENST00000428457H7BZ64
ENSG00000136205ENST00000434451C9JUW5
ENSG00000136205ENST00000442536Q68CZ2
ENSG00000136205ENST00000450444C9JHU5
ENSG00000136205ENST00000457718E9PCX8
ENSG00000136205ENST00000458317Q68CZ2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET interacts with TNS proteinsREACTOMER-HSA-8875513

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176431152007A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191945072009Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer.22
151409442004Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3.17
261664332015A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration.11
258143622015SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3.10
184242042008Cytogenetic and molecular characterization of a de-novo t(2p;7p) translocation involving TNS3 and EXOC6B genes in a boy with a complex syndromic phenotype.8
238036432013CpG dinucleotide-specific hypermethylation of the TNS3 gene promoter in human renal cell carcinoma.5
288218792017Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3.5
285152312017A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity.3

Citation

Dessen P

TNS3 (tensin 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42518/tns3