Identity
HGNC
LOCATION
17q21.33
LOCUSID
ALIAS
APRO5,APRO6,PIG49,TOB,TROB,TROB1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10140
MIM: 605523
HGNC: 11979
Ensembl: ENSG00000141232
Variants:
dbSNP: 10140
ClinVar: 10140
TCGA: ENSG00000141232
COSMIC: TOB1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000141232 | ENST00000268957 | P50616 |
| ENSG00000141232 | ENST00000499247 | P50616 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| RNA degradation | KEGG | ko03018 |
| RNA degradation | KEGG | hsa03018 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38617839 | 2024 | TOB1 modulates neutrophil phenotypes to influence gastric cancer progression and immunotherapy efficacy. | 0 |
| 38617839 | 2024 | TOB1 modulates neutrophil phenotypes to influence gastric cancer progression and immunotherapy efficacy. | 0 |
| 36002674 | 2023 | Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates with Malignant Progression and Poor Prognosis of Esophageal Squamous Cell Carcinoma. | 2 |
| 36002674 | 2023 | Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates with Malignant Progression and Poor Prognosis of Esophageal Squamous Cell Carcinoma. | 2 |
| 35186488 | 2022 | Involvement of TOB1 on autophagy in gastric cancer AGS cells via decreasing the activation of AKT/mTOR signaling pathway. | 4 |
| 35186488 | 2022 | Involvement of TOB1 on autophagy in gastric cancer AGS cells via decreasing the activation of AKT/mTOR signaling pathway. | 4 |
| 33786619 | 2021 | Identification of miR‑25‑3p as a tumor biomarker: Regulation of cellular functions via TOB1 in breast cancer. | 8 |
| 33786619 | 2021 | Identification of miR‑25‑3p as a tumor biomarker: Regulation of cellular functions via TOB1 in breast cancer. | 8 |
| 31891232 | 2020 | TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer. | 4 |
| 32307083 | 2020 | LncRNA WEE2-AS1 promotes proliferation and inhibits apoptosis in triple negative breast cancer cells via regulating miR-32-5p/TOB1 axis. | 17 |
| 31891232 | 2020 | TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer. | 4 |
| 32307083 | 2020 | LncRNA WEE2-AS1 promotes proliferation and inhibits apoptosis in triple negative breast cancer cells via regulating miR-32-5p/TOB1 axis. | 17 |
| 30529155 | 2019 | MicroRNA-371a-3p promotes progression of gastric cancer by targeting TOB1. | 15 |
| 30962003 | 2019 | Decreased expression levels of DAL-1 and TOB1 are associated with clinicopathological features and poor prognosis in gastric cancer. | 5 |
| 30529155 | 2019 | MicroRNA-371a-3p promotes progression of gastric cancer by targeting TOB1. | 15 |
Citation
Dessen P
TOB1 (transducer of ERBB2, 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42651/tob1
