Identity
HGNC
LOCATION
22q13.2
LOCUSID
ALIAS
APRO5,TOB4,TOBL,TROB2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10766
MIM: 607396
HGNC: 11980
Ensembl: ENSG00000183864
Variants:
dbSNP: 10766
ClinVar: 10766
TCGA: ENSG00000183864
COSMIC: TOB2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000183864 | ENST00000327492 | Q14106 |
| ENSG00000183864 | ENST00000434408 | B0QXZ4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| RNA degradation | KEGG | ko03018 |
| RNA degradation | KEGG | hsa03018 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32404348 | 2020 | Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation. | 9 |
| 32619704 | 2020 | MiR-375 promotes human periodontal ligament stem cells proliferation and osteogenic differentiation by targeting transducer of ERBB2, 2. | 2 |
| 32404348 | 2020 | Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation. | 9 |
| 32619704 | 2020 | MiR-375 promotes human periodontal ligament stem cells proliferation and osteogenic differentiation by targeting transducer of ERBB2, 2. | 2 |
| 25649327 | 2015 | Upregulation of miR-362-3p Modulates Proliferation and Anchorage-Independent Growth by Directly Targeting Tob2 in Hepatocellular Carcinoma. | 26 |
| 25649327 | 2015 | Upregulation of miR-362-3p Modulates Proliferation and Anchorage-Independent Growth by Directly Targeting Tob2 in Hepatocellular Carcinoma. | 26 |
| 22252318 | 2012 | Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities. | 28 |
| 22252318 | 2012 | Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities. | 28 |
| 21242960 | 2011 | Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation. | 40 |
| 21242960 | 2011 | Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation. | 40 |
| 19760502 | 2010 | Transactivation of ErbB-2 induced by tumor necrosis factor alpha promotes NF-kappaB activation and breast cancer cell proliferation. | 19 |
| 19940862 | 2010 | Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy. | 0 |
| 19760502 | 2010 | Transactivation of ErbB-2 induced by tumor necrosis factor alpha promotes NF-kappaB activation and breast cancer cell proliferation. | 19 |
| 19940862 | 2010 | Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy. | 0 |
| 12135500 | 2002 | Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. | 23 |
Citation
Dessen P
TOB2 (transducer of ERBB2, 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42652/tob2
