TOMM70 (translocase of outer mitochondrial membrane 70)

2016-05-01  

Identity

HGNC
LOCATION
3q12.2
LOCUSID
ALIAS
TOMM70A,Tom70

Other Information

Locus ID:

NCBI: 9868
MIM: 606081
HGNC: 11985
Ensembl: ENSG00000154174

Variants:

dbSNP: 9868
ClinVar: 9868
TCGA: ENSG00000154174
COSMIC: TOMM70

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154174ENST00000284320O94826

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Mitochondrial protein importREACTOMER-HSA-1268020
MitophagyREACTOMER-HSA-5205647
Pink/Parkin Mediated MitophagyREACTOMER-HSA-5205685
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
206283682010Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.38
169687022006Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import.36
241494402013The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.29
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
168228352006An internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway.16
293959202018TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer.14
217717902011Interaction between the human mitochondrial import receptors Tom20 and Tom70 in vitro suggests a chaperone displacement mechanism.13
234721962013Tom70 is essential for PINK1 import into mitochondria.12
186696402008Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain.11
250228982014Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy.10

Citation

Dessen P

TOMM70 (translocase of outer mitochondrial membrane 70)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/78309/tomm70