TONSL (tonsoku like, DNA repair protein)

2010-12-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
IKBR,NFKBIL2,SEMDSP
FUSION GENES

Other Information

Locus ID:

NCBI: 4796
MIM: 604546
HGNC: 7801
Ensembl: ENSG00000160949

Variants:

dbSNP: 4796
ClinVar: 4796
TCGA: ENSG00000160949
COSMIC: TONSL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160949ENST00000409379Q96HA7
ENSG00000160949ENST00000613741A0A087X1F6

Expression (GTEx)

0
5
10
15
20
25

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
210559852010A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.48
210559832010The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.47
273387932016H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.44
210559842010Identification of the MMS22L-TONSL complex that promotes homologous recombination.42
211131332010RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.27
277978182016The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress.18
294788072018The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.11
204854442010Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.9
211719932010Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study.8
307230512019Overexpression of TONSL might be an independent unfavorable prognostic indicator in hepatocellular carcinoma.1

Citation

Dessen P

TONSL (tonsoku like, DNA repair protein)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51776/tonsl