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TOP2A (DNA topoisomerase II alpha)

Identity

Alias_namesTOP2
topoisomerase (DNA) II alpha 170kDa
Other aliasTP2A
HGNC (Hugo) TOP2A
LocusID (NCBI) 7153
Atlas_Id 42659
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 40388521 and ends at 40417950 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C17orf75 (17q11.2) / TOP2A (17q21.2)EZH1 (17q21.2) / TOP2A (17q21.2)ILF3 (19p13.2) / TOP2A (17q21.2)
RBM17 (10p15.1) / TOP2A (17q21.2)C17orf75 17q11.2 / TOP2A 17q21.2EZH1 17q21.2 / TOP2A 17q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Breast: Ductal carcinoma
t(17;17)(q11;q21) C17orf75/TOP2A
EZH1/TOP2A (17q21)

External links

Nomenclature
HGNC (Hugo)TOP2A   11989
Cards
Entrez_Gene (NCBI)TOP2A  7153  DNA topoisomerase II alpha
AliasesTOP2; TP2A
GeneCards (Weizmann)TOP2A
Ensembl hg19 (Hinxton)ENSG00000131747 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131747 [Gene_View]  ENSG00000131747 [Sequence]  chr17:40388521-40417950 [Contig_View]  TOP2A [Vega]
ICGC DataPortalENSG00000131747
TCGA cBioPortalTOP2A
AceView (NCBI)TOP2A
Genatlas (Paris)TOP2A
WikiGenes7153
SOURCE (Princeton)TOP2A
Genetics Home Reference (NIH)TOP2A
Genomic and cartography
GoldenPath hg38 (UCSC)TOP2A  -     chr17:40388521-40417950 -  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOP2A  -     17q21.2   [Description]    (hg19-Feb_2009)
GoldenPathTOP2A - 17q21.2 [CytoView hg19]  TOP2A - 17q21.2 [CytoView hg38]
ImmunoBaseENSG00000131747
Mapping of homologs : NCBITOP2A [Mapview hg19]  TOP2A [Mapview hg38]
OMIM126430   
Gene and transcription
Genbank (Entrez)AF285157 AF285158 AF285159 AK024080 BC013429
RefSeq transcript (Entrez)NM_001067
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TOP2A
Cluster EST : UnigeneHs.156346 [ NCBI ]
CGAP (NCI)Hs.156346
Alternative Splicing GalleryENSG00000131747
Gene ExpressionTOP2A [ NCBI-GEO ]   TOP2A [ EBI - ARRAY_EXPRESS ]   TOP2A [ SEEK ]   TOP2A [ MEM ]
Gene Expression Viewer (FireBrowse)TOP2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7153
GTEX Portal (Tissue expression)TOP2A
Human Protein AtlasENSG00000131747-TOP2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11388   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11388  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11388
Splice isoforms : SwissVarP11388
Catalytic activity : Enzyme5.99.1.2 [ Enzyme-Expasy ]   5.99.1.25.99.1.2 [ IntEnz-EBI ]   5.99.1.2 [ BRENDA ]   5.99.1.2 [ KEGG ]   
PhosPhoSitePlusP11388
Domaine pattern : Prosite (Expaxy)TOPOISOMERASE_II (PS00177)    TOPRIM (PS50880)   
Domains : Interpro (EBI)DTHCT    HATPase_C    HATPase_C_sf    Ribosomal_S5_D2-typ_fold    Ribosomal_S5_D2-typ_fold_subgr    Topo_IIA    Topo_IIA-like_dom_sf    Topo_IIA_A/C    Topo_IIA_A/C_ab    Topo_IIA_B_C    Topo_IIA_bsu_dom2    TopoIIA_CS    TOPRIM_C    TOPRIM_domain    TOPRIM_TopoII   
Domain families : Pfam (Sanger)DNA_gyraseB (PF00204)    DNA_topoisoIV (PF00521)    DTHCT (PF08070)    HATPase_c (PF02518)    Toprim (PF01751)    TOPRIM_C (PF16898)   
Domain families : Pfam (NCBI)pfam00204    pfam00521    pfam08070    pfam02518    pfam01751    pfam16898   
Domain families : Smart (EMBL)TOP2c (SM00433)  TOP4c (SM00434)  
Conserved Domain (NCBI)TOP2A
DMDM Disease mutations7153
Blocks (Seattle)TOP2A
PDB (RSDB)1LWZ    1ZXM    1ZXN    4FM9    4R1F    5GWK   
PDB Europe1LWZ    1ZXM    1ZXN    4FM9    4R1F    5GWK   
PDB (PDBSum)1LWZ    1ZXM    1ZXN    4FM9    4R1F    5GWK   
PDB (IMB)1LWZ    1ZXM    1ZXN    4FM9    4R1F    5GWK   
Structural Biology KnowledgeBase1LWZ    1ZXM    1ZXN    4FM9    4R1F    5GWK   
SCOP (Structural Classification of Proteins)1LWZ    1ZXM    1ZXN    4FM9    4R1F    5GWK   
CATH (Classification of proteins structures)1LWZ    1ZXM    1ZXN    4FM9    4R1F    5GWK   
SuperfamilyP11388
Human Protein Atlas [tissue]ENSG00000131747-TOP2A [tissue]
Peptide AtlasP11388
HPRD00536
IPIIPI01011132   IPI00414101   IPI00879004   IPI00953043   IPI00478232   
Protein Interaction databases
DIP (DOE-UCLA)P11388
IntAct (EBI)P11388
FunCoupENSG00000131747
BioGRIDTOP2A
STRING (EMBL)TOP2A
ZODIACTOP2A
Ontologies - Pathways
QuickGOP11388
Ontology : AmiGOnuclear chromosome  magnesium ion binding  resolution of meiotic recombination intermediates  condensed chromosome  sister chromatid segregation  hematopoietic progenitor cell differentiation  DNA binding  chromatin binding  RNA binding  DNA topoisomerase type II (ATP-hydrolyzing) activity  DNA topoisomerase type II (ATP-hydrolyzing) activity  protein kinase C binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  nucleolus  centriole  DNA topological change  DNA topological change  DNA ligation  cellular response to DNA damage stimulus  chromosome segregation  female meiotic nuclear division  protein C-terminus binding  DNA-dependent ATPase activity  drug binding  DNA binding, bending  DNA topoisomerase complex (ATP-hydrolyzing)  viral integration complex  enzyme binding  apoptotic chromosome condensation  apoptotic chromosome condensation  protein-containing complex  embryonic cleavage  regulation of circadian rhythm  protein homodimerization activity  histone deacetylase binding  positive regulation of apoptotic process  ubiquitin binding  mitotic DNA integrity checkpoint  positive regulation of single stranded viral RNA replication via double stranded DNA intermediate  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  rhythmic process  negative regulation of DNA duplex unwinding  ribonucleoprotein complex  
Ontology : EGO-EBInuclear chromosome  magnesium ion binding  resolution of meiotic recombination intermediates  condensed chromosome  sister chromatid segregation  hematopoietic progenitor cell differentiation  DNA binding  chromatin binding  RNA binding  DNA topoisomerase type II (ATP-hydrolyzing) activity  DNA topoisomerase type II (ATP-hydrolyzing) activity  protein kinase C binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  nucleolus  centriole  DNA topological change  DNA topological change  DNA ligation  cellular response to DNA damage stimulus  chromosome segregation  female meiotic nuclear division  protein C-terminus binding  DNA-dependent ATPase activity  drug binding  DNA binding, bending  DNA topoisomerase complex (ATP-hydrolyzing)  viral integration complex  enzyme binding  apoptotic chromosome condensation  apoptotic chromosome condensation  protein-containing complex  embryonic cleavage  regulation of circadian rhythm  protein homodimerization activity  histone deacetylase binding  positive regulation of apoptotic process  ubiquitin binding  mitotic DNA integrity checkpoint  positive regulation of single stranded viral RNA replication via double stranded DNA intermediate  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  rhythmic process  negative regulation of DNA duplex unwinding  ribonucleoprotein complex  
NDEx NetworkTOP2A
Atlas of Cancer Signalling NetworkTOP2A
Wikipedia pathwaysTOP2A
Orthology - Evolution
OrthoDB7153
GeneTree (enSembl)ENSG00000131747
Phylogenetic Trees/Animal Genes : TreeFamTOP2A
HOGENOMP11388
Homologs : HomoloGeneTOP2A
Homology/Alignments : Family Browser (UCSC)TOP2A
Gene fusions - Rearrangements
Fusion : MitelmanC17orf75/TOP2A [17q11.2/17q21.2]  [t(17;17)(q11;q21)]  
Fusion : MitelmanEZH1/TOP2A [17q21.2/17q21.2]  [t(17;17)(q21;q21)]  
Fusion PortalC17orf75 17q11.2 TOP2A 17q21.2 BRCA
Fusion PortalEZH1 17q21.2 TOP2A 17q21.2 BRCA
Fusion : QuiverTOP2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOP2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOP2A
dbVarTOP2A
ClinVarTOP2A
1000_GenomesTOP2A 
Exome Variant ServerTOP2A
ExAC (Exome Aggregation Consortium)ENSG00000131747
GNOMAD BrowserENSG00000131747
Varsome BrowserTOP2A
Genetic variants : HAPMAP7153
Genomic Variants (DGV)TOP2A [DGVbeta]
DECIPHERTOP2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOP2A 
Mutations
ICGC Data PortalTOP2A 
TCGA Data PortalTOP2A 
Broad Tumor PortalTOP2A
OASIS PortalTOP2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOP2A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTOP2A
Mutations and Diseases : HGMDTOP2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TOP2A
DgiDB (Drug Gene Interaction Database)TOP2A
DoCM (Curated mutations)TOP2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TOP2A (select a term)
intoGenTOP2A
Cancer3DTOP2A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126430   
Orphanet548   
DisGeNETTOP2A
MedgenTOP2A
Genetic Testing Registry TOP2A
NextProtP11388 [Medical]
TSGene7153
GENETestsTOP2A
Target ValidationTOP2A
Huge Navigator TOP2A [HugePedia]
snp3D : Map Gene to Disease7153
BioCentury BCIQTOP2A
ClinGenTOP2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7153
Chemical/Pharm GKB GenePA354
Clinical trialTOP2A
Miscellaneous
canSAR (ICR)TOP2A (select the gene name)
DataMed IndexTOP2A
Probes
Litterature
PubMed449 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTOP2A
EVEXTOP2A
GoPubMedTOP2A
iHOPTOP2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:12:36 CET 2019
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