TOP3B (DNA topoisomerase III beta)

2003-05-01  

Identity

HGNC
LOCATION
22q11.22
LOCUSID
ALIAS
TOP3B1
FUSION GENES

Other Information

Locus ID:

NCBI: 8940
MIM: 603582
HGNC: 11993
Ensembl: ENSG00000100038

Variants:

dbSNP: 8940
ClinVar: 8940
TCGA: ENSG00000100038
COSMIC: TOP3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100038ENST00000357179O95985
ENSG00000100038ENST00000357179A0A024R1C2
ENSG00000100038ENST00000398793O95985
ENSG00000100038ENST00000398793A0A024R1C2
ENSG00000100038ENST00000424393C9JEI7
ENSG00000100038ENST00000430142C9JKE2
ENSG00000100038ENST00000434517C9JF56
ENSG00000100038ENST00000436282H7C4B0
ENSG00000100038ENST00000437103C9JTQ7
ENSG00000100038ENST00000437929C9JT00
ENSG00000100038ENST00000442653C9JHR0
ENSG00000100038ENST00000444502F2Z2A5
ENSG00000100038ENST00000449704C9JEQ1
ENSG00000100038ENST00000456075C9J9X4
ENSG00000100038ENST00000457179F2Z2A5
ENSG00000100038ENST00000457270H0Y6W0

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
Bloom's syndrome complexKEGGhsa_M00414
Bloom's syndrome complexKEGGM00414

References

Pubmed IDYearTitleCitations
245077162014Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation.73
272570632016RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals.19
280393242017Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction.11
294714952018Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization.7
115492882001M phase-specific association of human topoisomerase IIIbeta with chromosomes.4
209507302010Significance of topoisomerase IIIβ expression in breast ductal carcinomas: strong associations with disease-specific survival and metastasis.4
294902922018TOP3B: A Novel Candidate Gene in Juvenile Myoclonic Epilepsy?4
317959192019Loss of TOP3B leads to increased R-loop formation and genome instability.3
281768342017Structural basis of the interaction between Topoisomerase IIIβ and the TDRD3 auxiliary factor.2
153585192004Identification of the functional elements in the promoter region of human DNA topoisomerase IIIbeta gene.0

Citation

Dessen P

TOP3B (DNA topoisomerase III beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42661/top3b