Identity
HGNC
LOCATION
3q22.1
LOCUSID
ALIAS
Dpb11,TOP2BP1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11073
MIM: 607760
HGNC: 17008
Ensembl: ENSG00000163781
Variants:
dbSNP: 11073
ClinVar: 11073
TCGA: ENSG00000163781
COSMIC: TOPBP1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000163781 | ENST00000260810 | Q92547 |
| ENSG00000163781 | ENST00000572787 | I3L1F2 |
| ENSG00000163781 | ENST00000642236 | A0A2R8YD63 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38169561 | 2024 | NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway. | 1 |
| 38578830 | 2024 | Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates. | 0 |
| 38169561 | 2024 | NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway. | 1 |
| 38578830 | 2024 | Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates. | 0 |
| 36586311 | 2023 | Topoisomerase IIβ binding protein 1 serves as a novel prognostic biomarker for stage II-III colorectal cancer patients. | 0 |
| 37712702 | 2023 | Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function. | 1 |
| 36586311 | 2023 | Topoisomerase IIβ binding protein 1 serves as a novel prognostic biomarker for stage II-III colorectal cancer patients. | 0 |
| 37712702 | 2023 | Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function. | 1 |
| 35051531 | 2022 | Disrupting PHF8-TOPBP1 connection elicits a breast tumor-specific vulnerability to chemotherapeutics. | 3 |
| 35768646 | 2022 | Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. | 10 |
| 35842428 | 2022 | The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis. | 15 |
| 35880889 | 2022 | Interaction with TopBP1 Is Required for Human Papillomavirus 16 E2 Plasmid Segregation/Retention Function during Mitosis. | 6 |
| 35051531 | 2022 | Disrupting PHF8-TOPBP1 connection elicits a breast tumor-specific vulnerability to chemotherapeutics. | 3 |
| 35768646 | 2022 | Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. | 10 |
| 35842428 | 2022 | The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis. | 15 |
Citation
Dessen P
TOPBP1 (DNA topoisomerase II binding protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2005-11-01
Online version: http://atlasgeneticsoncology.org/gene/43070/topbp1
