TP53AIP1 (tumor protein p53 regulated apoptosis inducing protein 1)

2009-03-01 Affiliation

Identity

HGNC

TP53AIP1

LOCATION

11q24.3

LOCUSID

63970

ALIAS

P53AIP1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 63970
MIM: 605426
HGNC: 29984
Ensembl: ENSG00000120471

Variants:

dbSNP: 63970
ClinVar: 63970
TCGA: ENSG00000120471
COSMIC: TP53AIP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000120471	ENST00000458238	Q9HCN2
ENSG00000120471	ENST00000527504	Q9HCN2
ENSG00000120471	ENST00000530777	Q9HCN2
ENSG00000120471	ENST00000531399	Q9HCN2
ENSG00000120471	ENST00000602346	Q9HCN2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
p53 signaling pathway	KEGG	ko04115
Apoptosis	KEGG	ko04210
p53 signaling pathway	KEGG	hsa04115
Apoptosis	KEGG	hsa04210
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Transcription of Cell Death Genes	REACTOME	R-HSA-5633008
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	REACTOME	R-HSA-6803204

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD
PA128406956	fluorouracil	Chemical	ClinicalAnnotation	associated	PD
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation	associated	PD
PA445113	Neutropenia	Disease	ClinicalAnnotation	associated	PD
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation	associated	PD
PA449476	epirubicin	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
12019168	2002	p53AIP1 regulates the mitochondrial apoptotic pathway.	27
15004724	2004	Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line.	22
15657359	2005	Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells.	12
20800603	2010	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	12
14707453	2003	Changes in apoptosis and mitotic index, p53 and Ki67 expression in various types of oral leukoplakia.	9
22334068	2012	Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis.	8
19228369	2009	Combination of p53AIP1 and survivin expression is a powerful prognostic marker in non-small cell lung cancer.	7
17851056	2008	p53AIP1 expression can be a prognostic marker in non-small cell lung cancer.	4
30864684	2019	Extracellular vesicle‑delivered miR‑505‑5p, as a diagnostic biomarker of early lung adenocarcinoma, inhibits cell apoptosis by targeting TP53AIP1.	3
18277906	2008	Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori.	2

Citation

Dessen P

TP53AIP1 (tumor protein p53 regulated apoptosis inducing protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50785/tp53aip1