TP53I3 (tumor protein p53 inducible protein 3)

2003-02-01  

Identity

HGNC
LOCATION
2p23.3
LOCUSID
ALIAS
PIG3
FUSION GENES

Other Information

Locus ID:

NCBI: 9540
MIM: 605171
HGNC: 19373
Ensembl: ENSG00000115129

Variants:

dbSNP: 9540
ClinVar: 9540
TCGA: ENSG00000115129
COSMIC: TP53I3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115129ENST00000238721Q53FA7
ENSG00000115129ENST00000335934Q53FA7
ENSG00000115129ENST00000407482Q53FA7
ENSG00000115129ENST00000413037H7BZH6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
p53 signaling pathwayKEGGhsa04115
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainREACTOMER-HSA-6803205

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
200236972010The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage.27
224616242012p53-induced gene 3 mediates cell death induced by glutathione peroxidase 3.26
193365522009Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development.25
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23
264644642016Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.21
261337722015PIG3 plays an oncogenic role in papillary thyroid cancer by activating the PI3K/AKT/PTEN pathway.13
193492812009Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3.12
195730802009Common genetic variants in candidate genes and risk of familial lymphoid malignancies.12

Citation

Dessen P

TP53I3 (tumor protein p53 inducible protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42670/tp53i3