TP73 (tumor protein p73)

2003-02-01  

Identity

HGNC
LOCATION
1p36.32
LOCUSID
ALIAS
P73
FUSION GENES

Other Information

Locus ID:

NCBI: 7161
MIM: 601990
HGNC: 12003
Ensembl: ENSG00000078900

Variants:

dbSNP: 7161
ClinVar: 7161
TCGA: ENSG00000078900
COSMIC: TP73

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078900ENST00000346387O15350
ENSG00000078900ENST00000354437O15350
ENSG00000078900ENST00000357733O15350
ENSG00000078900ENST00000378280A0A0C4DFW9
ENSG00000078900ENST00000378285O15350
ENSG00000078900ENST00000378288O15350
ENSG00000078900ENST00000378290O15350
ENSG00000078900ENST00000378295O15350
ENSG00000078900ENST00000378295A0A024R4C3
ENSG00000078900ENST00000603362O15350
ENSG00000078900ENST00000604074O15350
ENSG00000078900ENST00000604479O15350

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
p53 signaling pathwayKEGGhsa04115
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of PUMA and translocation to mitochondriaREACTOMER-HSA-139915
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Death Receptors and LigandsREACTOMER-HSA-6803211
TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseREACTOMER-HSA-6803204
TP53 Regulates Transcription of Caspase Activators and CaspasesREACTOMER-HSA-6803207
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainREACTOMER-HSA-6803205
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through Association with Co-factorsREACTOMER-HSA-6804759

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
92887591997Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.370
164134712006p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis.179
178896692007RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein.152
146340232004p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation.126
214277672011The p53 family: guardians of maternal reproduction.122
156781062005The ubiquitin-protein ligase Itch regulates p73 stability.111
174469292007The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers.107
150707302004Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.92
191116602008PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.92
127667782003Differential regulation of E2F1 apoptotic target genes in response to DNA damage.87

Citation

Dessen P

TP73 (tumor protein p73)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/205/tp73