TPI1 (triosephosphate isomerase 1)

2007-02-01  

Identity

HGNC
TPI1
LOCATION
12p13.31
LOCUSID
7167
ALIAS
HEL-S-49,TIM,TPI,TPID
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7167
MIM: 190450
HGNC: 12009
Ensembl: ENSG00000111669

Variants:

dbSNP: 7167
ClinVar: 7167
TCGA: ENSG00000111669
COSMIC: TPI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111669ENST00000229270P60174
ENSG00000111669ENST00000396705P60174
ENSG00000111669ENST00000396705V9HWK1
ENSG00000111669ENST00000462761U3KPS5
ENSG00000111669ENST00000488464P60174
ENSG00000111669ENST00000493987U3KPZ0
ENSG00000111669ENST00000495834U3KQF3
ENSG00000111669ENST00000535434P60174
ENSG00000111669ENST00000613953P60174

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Fructose and mannose metabolismKEGGko00051
Inositol phosphate metabolismKEGGko00562
Glycolysis / GluconeogenesisKEGGhsa00010
Fructose and mannose metabolismKEGGhsa00051
Inositol phosphate metabolismKEGGhsa00562
Metabolic pathwaysKEGGhsa01100
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Glycolysis, core module involving three-carbon compoundsKEGGhsa_M00002
Gluconeogenesis, oxaloacetate => fructose-6PKEGGhsa_M00003
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
Glycolysis, core module involving three-carbon compoundsKEGGM00002
Gluconeogenesis, oxaloacetate => fructose-6PKEGGM00003
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GlycolysisREACTOMER-HSA-70171
GluconeogenesisREACTOMER-HSA-70263

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381300742024TPI1 promotes MAPK/ERK-induced EMT, cell migration and invasion in lung adenocarcinoma.2
386321012024Generation and analysis of TPI deficiency zebrafish model.0
381300742024TPI1 promotes MAPK/ERK-induced EMT, cell migration and invasion in lung adenocarcinoma.2
386321012024Generation and analysis of TPI deficiency zebrafish model.0
367155442023LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.5
381026532023Triosephosphate isomerase 1 may be a risk predictor in laryngeal squamous cell carcinoma: a multi-centered study integrating bulk RNA, single-cell RNA, and protein immunohistochemistry.2
381178322023Knockdown of TPI in human dermal microvascular endothelial cells and its impact on angiogenesis in vitro.0
367155442023LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.5
381026532023Triosephosphate isomerase 1 may be a risk predictor in laryngeal squamous cell carcinoma: a multi-centered study integrating bulk RNA, single-cell RNA, and protein immunohistochemistry.2
381178322023Knockdown of TPI in human dermal microvascular endothelial cells and its impact on angiogenesis in vitro.0
354827242022Expression of vimentin, TPI and MAT2A in human dermal microvascular endothelial cells during angiogenesis in vitro.2
355090672022TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.22
354827242022Expression of vimentin, TPI and MAT2A in human dermal microvascular endothelial cells during angiogenesis in vitro.2
355090672022TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.22
342332932021Glycolysis- and immune-related novel prognostic biomarkers of Ewing's sarcoma: glucuronic acid epimerase and triosephosphate isomerase 1.7

Citation

Dessen P

TPI1 (triosephosphate isomerase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46334/tpi1