TPP2 (tripeptidyl peptidase 2)

2009-04-01  

Identity

HGNC
TPP2
LOCATION
13q33.1
LOCUSID
7174
ALIAS
IMD78,TPP-2,TPP-II,TPPII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7174
MIM: 190470
HGNC: 12016
Ensembl: ENSG00000134900

Variants:

dbSNP: 7174
ClinVar: 7174
TCGA: ENSG00000134900
COSMIC: TPP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134900ENST00000376052Q5VZU9
ENSG00000134900ENST00000376065P29144
ENSG00000134900ENST00000493770A0A494C0X4
ENSG00000134900ENST00000650757A0A494C1S6
ENSG00000134900ENST00000651448A0A494C1S4
ENSG00000134900ENST00000651544A0A494C0U1
ENSG00000134900ENST00000651748A0A494C159
ENSG00000134900ENST00000651921A0A494C1L2
ENSG00000134900ENST00000652033A0A494C0A3
ENSG00000134900ENST00000652308A0A494C1B8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
179011162007The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse.89
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191554702009ISCOMATRIX adjuvant induces efficient cross-presentation of tumor antigen by dendritic cells via rapid cytosolic antigen delivery and processing via tripeptidyl peptidase II.28
168494492006Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation.26
254144422015Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency.15
255258762014Dual proteolytic pathways govern glycolysis and immune competence.13
217716702012Structure and function of tripeptidyl peptidase II, a giant cytosolic protease.9
229868082013Tripeptidyl peptidase II in human oral squamous cell carcinoma.9
261699842015Novel protein-protein interactions of TPPII, p53, and SIRT7.8
167623212006TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints.6

Citation

Dessen P

TPP2 (tripeptidyl peptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-04-01

Online version: http://atlasgeneticsoncology.org/gene/50836/tpp2