Identity
HGNC
LOCATION
5p15.33
LOCUSID
ALIAS
TPPP/p25,TPPP1,p24,p25,p25alpha
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11076
MIM: 608773
HGNC: 24164
Ensembl: ENSG00000171368
Variants:
dbSNP: 11076
ClinVar: 11076
TCGA: ENSG00000171368
COSMIC: TPPP
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000171368 | ENST00000360578 | O94811 |
| ENSG00000171368 | ENST00000360578 | Q4L233 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38391951 | 2024 | Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP. | 0 |
| 38391951 | 2024 | Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP. | 0 |
| 35062349 | 2022 | HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk. | 12 |
| 35062349 | 2022 | HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk. | 12 |
| 34831132 | 2021 | Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein. | 1 |
| 34831132 | 2021 | Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein. | 1 |
| 31505170 | 2019 | Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8. | 2 |
| 31522887 | 2019 | The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination. | 51 |
| 31631174 | 2019 | YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways. | 20 |
| 31505170 | 2019 | Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8. | 2 |
| 31522887 | 2019 | The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination. | 51 |
| 31631174 | 2019 | YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways. | 20 |
| 27671864 | 2017 | Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins. | 13 |
| 28074911 | 2017 | Further evidence for microtubule-independent dimerization of TPPP/p25. | 9 |
| 28271739 | 2017 | Role of the microtubule-associated TPPP/p25 in Parkinson's and related diseases and its therapeutic potential. | 11 |
Citation
Dessen P
TPPP (tubulin polymerization promoting protein)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/50011/tppp
