TPSAB1 (tryptase alpha/beta 1)

2007-02-01  

Identity

HGNC
TPSAB1
LOCATION
16p13.3
LOCUSID
7177
ALIAS
TPS1,TPS2,TPSB1,TPSB2,Tryptase-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7177
MIM: 191080
HGNC: 12019
Ensembl: ENSG00000172236

Variants:

dbSNP: 7177
ClinVar: 7177
TCGA: ENSG00000172236
COSMIC: TPSAB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172236ENST00000338844Q15661
ENSG00000172236ENST00000461509J3QTS8
ENSG00000172236ENST00000561736A0A0C4DGM1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
160271502005Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins.86
123971762002Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders.46
245071592014Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.36
223638242012Association of mast cell-derived VEGF and proteases in Dengue shock syndrome.34
239916862013High density of tryptase-positive mast cells in human colorectal cancer: a poor prognostic factor related to protease-activated receptor 2 expression.32
214938972011Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation.30
226139922012Mast cell tryptase induces microglia activation via protease-activated receptor 2 signaling.30
217077112011Tissue remodelling in breast cancer: human mast cell tryptase as an initiator of myofibroblast differentiation.27
249155682014Correlation between serum tryptase, mast cells positive to tryptase and microvascular density in colo-rectal cancer patients: possible biological-clinical significance.26
277498432016Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.20

Citation

Dessen P

TPSAB1 (tryptase alpha/beta 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45901/tpsab1