Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2)

Identity

Alias_symbol (synonym)TPIP
Other alias
HGNC (Hugo) TPTE2
LocusID (NCBI) 93492
Atlas_Id 53335
Location 13q12.11  [Link to chromosome band 13q12]
Location_base_pair Starts at 19422879 and ends at 19536763 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNMBP (10q24.2) / TPTE2 (13q12.11)DNMBP 10q24.2 / TPTE2 13q12.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;13)(q24;q12) DNMBP/TPTE2

External links

Nomenclature
HGNC (Hugo)TPTE2   17299
Cards
Entrez_Gene (NCBI)TPTE2  93492  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
AliasesTPIP
GeneCards (Weizmann)TPTE2
Ensembl hg19 (Hinxton)ENSG00000132958 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132958 [Gene_View]  ENSG00000132958 [Sequence]  chr13:19422879-19536763 [Contig_View]  TPTE2 [Vega]
ICGC DataPortalENSG00000132958
TCGA cBioPortalTPTE2
AceView (NCBI)TPTE2
Genatlas (Paris)TPTE2
WikiGenes93492
SOURCE (Princeton)TPTE2
Genetics Home Reference (NIH)TPTE2
Genomic and cartography
GoldenPath hg38 (UCSC)TPTE2  -     chr13:19422879-19536763 -  13q12.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPTE2  -     13q12.11   [Description]    (hg19-Feb_2009)
GoldenPathTPTE2 - 13q12.11 [CytoView hg19]  TPTE2 - 13q12.11 [CytoView hg38]
ImmunoBaseENSG00000132958
Mapping of homologs : NCBITPTE2 [Mapview hg19]  TPTE2 [Mapview hg38]
OMIM606791   
Gene and transcription
Genbank (Entrez)AJ421032 AJ421033 AK301741 AL079582 AY219890
RefSeq transcript (Entrez)NM_001141968 NM_001271850 NM_130785 NM_199254 NM_199255
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TPTE2
Cluster EST : UnigeneHs.377488 [ NCBI ]
CGAP (NCI)Hs.377488
Alternative Splicing GalleryENSG00000132958
Gene ExpressionTPTE2 [ NCBI-GEO ]   TPTE2 [ EBI - ARRAY_EXPRESS ]   TPTE2 [ SEEK ]   TPTE2 [ MEM ]
Gene Expression Viewer (FireBrowse)TPTE2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)93492
GTEX Portal (Tissue expression)TPTE2
Human Protein AtlasENSG00000132958-TPTE2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6XPS3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6XPS3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6XPS3
Splice isoforms : SwissVarQ6XPS3
PhosPhoSitePlusQ6XPS3
Domaine pattern : Prosite (Expaxy)C2_TENSIN (PS51182)    PPASE_TENSIN (PS51181)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    Prot-tyrosine_phosphatase-like    Tensin_C2-dom    Tensin_phosphatase    Tyr_Pase_AS    Volt_channel_dom_sf   
Domain families : Pfam (Sanger)DSPc (PF00782)    PTEN_C2 (PF10409)   
Domain families : Pfam (NCBI)pfam00782    pfam10409   
Domain families : Smart (EMBL)PTEN_C2 (SM01326)  
Conserved Domain (NCBI)TPTE2
DMDM Disease mutations93492
Blocks (Seattle)TPTE2
SuperfamilyQ6XPS3
Human Protein Atlas [tissue]ENSG00000132958-TPTE2 [tissue]
Peptide AtlasQ6XPS3
HPRD06003
IPIIPI00418438   IPI00480172   IPI00719421   IPI01018832   IPI00941380   IPI00915317   IPI00935789   
Protein Interaction databases
DIP (DOE-UCLA)Q6XPS3
IntAct (EBI)Q6XPS3
FunCoupENSG00000132958
BioGRIDTPTE2
STRING (EMBL)TPTE2
ZODIACTPTE2
Ontologies - Pathways
QuickGOQ6XPS3
Ontology : AmiGOGolgi membrane  protein tyrosine phosphatase activity  endoplasmic reticulum membrane  phosphatidylinositol biosynthetic process  protein tyrosine/serine/threonine phosphatase activity  integral component of membrane  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  peptidyl-tyrosine dephosphorylation  
Ontology : EGO-EBIGolgi membrane  protein tyrosine phosphatase activity  endoplasmic reticulum membrane  phosphatidylinositol biosynthetic process  protein tyrosine/serine/threonine phosphatase activity  integral component of membrane  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  peptidyl-tyrosine dephosphorylation  
NDEx NetworkTPTE2
Atlas of Cancer Signalling NetworkTPTE2
Wikipedia pathwaysTPTE2
Orthology - Evolution
OrthoDB93492
GeneTree (enSembl)ENSG00000132958
Phylogenetic Trees/Animal Genes : TreeFamTPTE2
HOGENOMQ6XPS3
Homologs : HomoloGeneTPTE2
Homology/Alignments : Family Browser (UCSC)TPTE2
Gene fusions - Rearrangements
Fusion : MitelmanDNMBP/TPTE2 [10q24.2/13q12.11]  [t(10;13)(q24;q12)]  
Fusion PortalDNMBP 10q24.2 TPTE2 13q12.11 LUSC
Fusion : QuiverTPTE2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPTE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPTE2
dbVarTPTE2
ClinVarTPTE2
1000_GenomesTPTE2 
Exome Variant ServerTPTE2
ExAC (Exome Aggregation Consortium)ENSG00000132958
GNOMAD BrowserENSG00000132958
Varsome BrowserTPTE2
Genetic variants : HAPMAP93492
Genomic Variants (DGV)TPTE2 [DGVbeta]
DECIPHERTPTE2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPTE2 
Mutations
ICGC Data PortalTPTE2 
TCGA Data PortalTPTE2 
Broad Tumor PortalTPTE2
OASIS PortalTPTE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPTE2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTPTE2
Mutations and Diseases : HGMDTPTE2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TPTE2
DgiDB (Drug Gene Interaction Database)TPTE2
DoCM (Curated mutations)TPTE2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPTE2 (select a term)
intoGenTPTE2
Cancer3DTPTE2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606791   
Orphanet
DisGeNETTPTE2
MedgenTPTE2
Genetic Testing Registry TPTE2
NextProtQ6XPS3 [Medical]
TSGene93492
GENETestsTPTE2
Target ValidationTPTE2
Huge Navigator TPTE2 [HugePedia]
snp3D : Map Gene to Disease93492
BioCentury BCIQTPTE2
ClinGenTPTE2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD93492
Chemical/Pharm GKB GenePA134917664
Clinical trialTPTE2
Miscellaneous
canSAR (ICR)TPTE2 (select the gene name)
DataMed IndexTPTE2
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTPTE2
EVEXTPTE2
GoPubMedTPTE2
iHOPTPTE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Nov 13 18:12:51 CET 2019
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