TRAF5 (TNF receptor associated factor 5)

2003-08-01  

Identity

HGNC
LOCATION
1q32.3
LOCUSID
ALIAS
MGC:39780,RNF84
FUSION GENES

Other Information

Locus ID:

NCBI: 7188
MIM: 602356
HGNC: 12035
Ensembl: ENSG00000082512

Variants:

dbSNP: 7188
ClinVar: 7188
TCGA: ENSG00000082512
COSMIC: TRAF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000082512ENST00000261464O00463
ENSG00000082512ENST00000336184O00463
ENSG00000082512ENST00000367004O00463

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Small cell lung cancerKEGGko05222
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
128428942003Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.113
157089702005TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs.74
203313782010Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
189907582008Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma.26
201617882010TRAF5 is a downstream target of MAVS in antiviral innate immune signaling.25
237745062013HIV-1 Nef interacts with HCV Core, recruits TRAF2, TRAF5 and TRAF6, and stimulates HIV-1 replication in macrophages.17
225932072012Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation.16
264533052015TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression.14
172770032007Investigation of association between the TRAF family genes and RA susceptibility.13

Citation

Dessen P

TRAF5 (TNF receptor associated factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42687/traf5