TRAIP (TRAF interacting protein)

2003-08-01  

Identity

HGNC
TRAIP
LOCATION
3p21.31
LOCUSID
10293
ALIAS
RNF206,SCKL9,TRIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10293
MIM: 605958
HGNC: 30764
Ensembl: ENSG00000183763

Variants:

dbSNP: 10293
ClinVar: 10293
TCGA: ENSG00000183763
COSMIC: TRAIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183763ENST00000331456Q9BWF2
ENSG00000183763ENST00000469027E7ETV1
ENSG00000183763ENST00000473195E7EVC4
ENSG00000183763ENST00000482243E7EW89
ENSG00000183763ENST00000482582E7EN91

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
146763042003The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor.37
265957692016TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.28
191517492009The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells.25
267114992016TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.24
257163172015Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction.18
308426572019TRAIP is a master regulator of DNA interstrand crosslink repair.18
182005092008Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease.13
245532862014TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η.13
267810882016TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage.12
210687522011The TRAF-interacting protein (TRIP) is a regulator of keratinocyte proliferation.11

Citation

Dessen P

TRAIP (TRAF interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42705/traip