TREM1 (triggering receptor expressed on myeloid cells 1)

2012-09-01 Affiliation

Identity

HGNC

TREM1

LOCATION

6p21.1

LOCUSID

54210

ALIAS

CD354,TREM-1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54210
MIM: 605085
HGNC: 17760
Ensembl: ENSG00000124731

Variants:

dbSNP: 54210
ClinVar: 54210
TCGA: ENSG00000124731
COSMIC: TREM1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000124731	ENST00000244709	Q9NP99
ENSG00000124731	ENST00000244709	Q38L15
ENSG00000124731	ENST00000334475	Q9NP99
ENSG00000124731	ENST00000589614	K7EKM5
ENSG00000124731	ENST00000591620	Q9NP99

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19230638	2009	TREM and TREM-like receptors in inflammation and disease.	150
12646648	2003	A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response.	102
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20640189	2010	Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease.	58
17785845	2007	Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes.	54
15067076	2004	Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival.	51
12645956	2003	The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44.	45
21148811	2011	Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.	40
19596984	2009	TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia.	39
25595774	2015	Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.	38

Citation

Dessen P

TREM1 (triggering receptor expressed on myeloid cells 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52855/trem1