TREM2 (triggering receptor expressed on myeloid cells 2)

2016-08-01  

Identity

HGNC
LOCATION
6p21.1
LOCUSID
ALIAS
PLOSL2,TREM-2,Trem2a,Trem2b,Trem2c

Other Information

Locus ID:

NCBI: 54209
MIM: 605086
HGNC: 17761
Ensembl: ENSG00000095970

Variants:

dbSNP: 54209
ClinVar: 54209
TCGA: ENSG00000095970
COSMIC: TREM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095970ENST00000338469Q9NZC2
ENSG00000095970ENST00000373113Q9NZC2
ENSG00000095970ENST00000373113Q5TCX1
ENSG00000095970ENST00000373122Q9NZC2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
231509342013TREM2 variants in Alzheimer's disease.810
231509082013Variant of TREM2 associated with the risk of Alzheimer's disease.707
289306632017The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.297
120804852002Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.200
257323052015TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.196
249908812014TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.194
287149762017Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.181
274770182016TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.156
192306382009TREM and TREM-like receptors in inflammation and disease.150
288020382017TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.135

Citation

Dessen P

TREM2 (triggering receptor expressed on myeloid cells 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55900/trem2