TREML2 (triggering receptor expressed on myeloid cells like 2)

2014-11-01 Affiliation

Identity

HGNC

TREML2

LOCATION

6p21.1

LOCUSID

79865

ALIAS

C6orf76,TLT-2,TLT2,dJ238O23.1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 79865
MIM: 609715
HGNC: 21092
Ensembl: ENSG00000112195

Variants:

dbSNP: 79865
ClinVar: 79865
TCGA: ENSG00000112195
COSMIC: TREML2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112195	ENST00000483722	Q5T2D2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933

References

Pubmed ID	Year	Title	Citations
19544488	2009	B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction.	80
18650384	2008	Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses.	64
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
24439484	2014	Missense variant in TREML2 protects against Alzheimer's disease.	44
16670310	2006	Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation.	20
27939925	2017	A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression.	15
27084067	2016	Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set.	8
26797517	2017	A Missense Variant in TREML2 Reduces Risk of Alzheimer's Disease in a Han Chinese Population.	2
31044564	2019	A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276.	2
29778423	2018	Genetic variants of TREML2 are associated with HLA-B27-positive ankylosing spondylitis.	1

Citation

Dessen P

TREML2 (triggering receptor expressed on myeloid cells like 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75133/treml2