TRIM11 (tripartite motif containing 11)

2014-01-01  

Identity

HGNC
TRIM11
LOCATION
1q42.13
LOCUSID
81559
ALIAS
BIA1,RNF92
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81559
MIM: 607868
HGNC: 16281
Ensembl: ENSG00000154370

Variants:

dbSNP: 81559
ClinVar: 81559
TCGA: ENSG00000154370
COSMIC: TRIM11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154370ENST00000284551Q96F44
ENSG00000154370ENST00000366699Q96F44
ENSG00000154370ENST00000493030R4GMV1
ENSG00000154370ENST00000602308R4GNC3
ENSG00000154370ENST00000602582R4GNB9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
182480902008TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.100
274988652016TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy.28
273291032016TRIM11 overexpression promotes proliferation, migration and invasion of lung cancer cells.25
231784882013TRIM11 is overexpressed in high-grade gliomas and promotes proliferation, invasion, migration and glial tumor growth.24
278886252016TRIM11, a direct target of miR-24-3p, promotes cell proliferation and inhibits apoptosis in colon cancer.23
169046692006TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system.18
236754672013TRIM11 negatively regulates IFNβ production and antiviral activity by targeting TBK1.18
282448562017TRIM11 Upregulation Contributes to Proliferation, Invasion, and EMT of Hepatocellular Carcinoma Cells.12
277376912016An HIV-1 capsid binding protein TRIM11 accelerates viral uncoating.9
182758502008Trim11 increases expression of dopamine beta-hydroxylase gene by interacting with Phox2b.7

Citation

Dessen P

TRIM11 (tripartite motif containing 11)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53786/trim11