TRIM16 (tripartite motif containing 16)

2009-05-01  

Identity

HGNC
LOCATION
17p12
LOCUSID
ALIAS
EBBP
FUSION GENES

Other Information

Locus ID:

NCBI: 10626
MIM: 609505
HGNC: 17241
Ensembl: ENSG00000221926

Variants:

dbSNP: 10626
ClinVar: 10626
TCGA: ENSG00000221926
COSMIC: TRIM16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000221926ENST00000336708O95361
ENSG00000221926ENST00000416464B3KP96
ENSG00000221926ENST00000494759K7EJH2
ENSG00000221926ENST00000577372J3QKY5
ENSG00000221926ENST00000577446K7ENN8
ENSG00000221926ENST00000577886O95361
ENSG00000221926ENST00000578237O95361
ENSG00000221926ENST00000578744K7EL43
ENSG00000221926ENST00000579219J3QLP0
ENSG00000221926ENST00000580110J3QR69
ENSG00000221926ENST00000581200J3QL38
ENSG00000221926ENST00000649191O95361

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
276935062016TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.71
226294022012TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members.32
207299202010TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells.18
301435142018TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy.15
191472772009The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation.12
165754082006The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion.11
166360642006The estrogen-responsive B box protein is a novel regulator of the retinoid signal.11
269024252016High TDP43 expression is required for TRIM16-induced inhibition of cancer cell growth and correlated with good prognosis of neuroblastoma and breast cancer patients.11
119191862002The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation.10
234220022013TRIM16 inhibits neuroblastoma cell proliferation through cell cycle regulation and dynamic nuclear localization.10

Citation

Dessen P

TRIM16 (tripartite motif containing 16)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50870/trim16