TRIM2 (tripartite motif containing 2)

2019-04-01  

Identity

HGNC
LOCATION
4q31.3
LOCUSID
ALIAS
CMT2R,RNF86
FUSION GENES

Other Information

Locus ID:

NCBI: 23321
MIM: 614141
HGNC: 15974
Ensembl: ENSG00000109654

Variants:

dbSNP: 23321
ClinVar: 23321
TCGA: ENSG00000109654
COSMIC: TRIM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109654ENST00000338700Q9C040
ENSG00000109654ENST00000433687C9J084
ENSG00000109654ENST00000437508Q9C040
ENSG00000109654ENST00000441616C9JVI3
ENSG00000109654ENST00000460908A0A0J9YY97
ENSG00000109654ENST00000482578A0A0J9YW70
ENSG00000109654ENST00000494872A0A0J9YX34
ENSG00000109654ENST00000502281A0A0J9YXY2
ENSG00000109654ENST00000632856A0A0J9YW70

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
217207222012Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β.48
265146222015TRIM-NHL proteins in development and disease.24
258937922015Exome sequencing reveals homozygous TRIM2 mutation in a patient with early onset CMT and bilateral vocal cord paralysis.5
300668832018TRIM2 regulates the development and metastasis of tumorous cells of osteosarcoma.5
307262152019TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.3
309165962019TRIM2 is a novel promoter of human colorectal cancer.2
248177352014Expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal NHL domain of human TRIM2.1
296283592018Gene expression-phenotype associations in adults with eosinophilic esophagitis.1
299584632018Exploring the Roles of CREBRF and TRIM2 in the Regulation of Angiogenesis by High-Density Lipoproteins.1

Citation

Dessen P

TRIM2 (tripartite motif containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57840/trim2