TRIM21 (tripartite motif containing 21)

2007-02-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
RNF81,RO52,Ro/SSA,SSA,SSA1

Other Information

Locus ID:

NCBI: 6737
MIM: 109092
HGNC: 11312
Ensembl: ENSG00000132109

Variants:

dbSNP: 6737
ClinVar: 6737
TCGA: ENSG00000132109
COSMIC: TRIM21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132109ENST00000254436P19474
ENSG00000132109ENST00000533692H0YDP8

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Systemic lupus erythematosusKEGGko05322
Systemic lupus erythematosusKEGGhsa05322
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
STING mediated induction of host immune responsesREACTOMER-HSA-1834941
Regulation of innate immune responses to cytosolic DNAREACTOMER-HSA-3134975
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
210451302010Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21).165
174007542007Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function.132
234556752013Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21.126
186413152008The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3.106
184208152008TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.75
263471392015TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.72
192651572009TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response.71
169062252006Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block.50
166703392006The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death.44
206686742010Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.42

Citation

Dessen P

TRIM21 (tripartite motif containing 21)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46025/trim21