TRIM26 (tripartite motif containing 26)

2003-11-01  

Identity

HGNC
LOCATION
6p22.1
LOCUSID
ALIAS
AFP,RNF95,ZNF173
FUSION GENES

Other Information

Locus ID:

NCBI: 7726
MIM: 600830
HGNC: 12962
Ensembl: ENSG00000234127

Variants:

dbSNP: 7726
ClinVar: 7726
TCGA: ENSG00000234127
COSMIC: TRIM26

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000234127ENST00000416596A2AE48
ENSG00000234127ENST00000418026Q5SPU2
ENSG00000234127ENST00000434785A2AE50
ENSG00000234127ENST00000437089Q12899
ENSG00000234127ENST00000437089A0A024RCP3
ENSG00000234127ENST00000453195Q12899
ENSG00000234127ENST00000453195A0A024RCP3
ENSG00000234127ENST00000454678Q12899
ENSG00000234127ENST00000454678A0A024RCP3

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
224337152012Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes.30
205930132010A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.20
260436852015TRIM26 functions as a novel tumor suppressor of hepatocellular carcinoma and its downregulation contributes to worse prognosis.17
266113592016Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response.13
296101522018NTH1 Is a New Target for Ubiquitylation-Dependent Regulation by TRIM26 Required for the Cellular Response to Oxidative Stress.3
222942752012Association study between TRIM26 polymorphisms and risk of aspirin-exacerbated respiratory disease.1
299565002018A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response.1
309272732019Overexpression of TRIM26 suppresses the proliferation, metastasis, and glycolysis in papillary thyroid carcinoma cells.0

Citation

Dessen P

TRIM26 (tripartite motif containing 26)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42699/trim26